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. 1971 Jun;25(2):343–349. doi: 10.1038/bjc.1971.44

Immunofluorescent Localisation of Human Alpha Fetoprotein in Fetal and Neonatal Livers and Cultured Cells from Hepatocellular Carcinoma

J A Smith, T I Francis, G M Edington, A O Williams
PMCID: PMC2008448  PMID: 4329952

Abstract

The indirect immunofluorescence technique demonstrated that human alpha fetoprotein (AFP) was present in a focal pattern in the cytoplasm of malignant liver cells of patients whose sera contained AFP. A few fibroblastlike cells in tissue culture of liver biopsies from patients with hepato-cellular carcinoma and AFP in their sera also had the protein. The intracellular localisation of human AFP was confirmed by centrifugation of washed, homogenised and ultra-sonically disrupted neonatal liver cells. Examination of livers of fetuses and neonates showed that AFP was present predominantly in the periportal parenchymal cells.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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