Abstract
The responses of four murine lymphomata, transplanted in their syngeneic hosts and differing widely in their biological properties such as tendency to metastasize and “strength” of tumour specific antigen, to immunotherapy, were investigated. Following the injection of a known number of tumour cells, the mice were treated either by administration of irradiated tumour cells, living BCG or both. In general, the response to BCG alone was small even in the most responsive tumours, irradiated cells were more effective and the best results were obtained by a combination of the two procedures. “Cures” were only obtained with the most antigenic of the tumours tested and then only when the live tumour cells were inoculated intraperitoneally. The effect of these treatments on the rate of growth of tumour when the cells were given subcutaneously was small but the rate at which metastatic spread occurred from the s.c. site was slowed and for one of these tumours this was quite marked.
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Selected References
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- Alexander P., Bensted J., Delorme E. J., Hall J. G., Hodgett J. The cellular immune response to primary sarcomata in rats. II. Abnormal responses of nodes draining the tumour. Proc R Soc Lond B Biol Sci. 1969 Nov 18;174(1035):237–251. doi: 10.1098/rspb.1969.0090. [DOI] [PubMed] [Google Scholar]
- Currie G. A. Active immunotherapy with Corynebacterium parvum and chemotherapy in murine fibrosarcomas. Br Med J. 1970 Feb 28;1(5695):541–544. doi: 10.1136/bmj.1.5695.541. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HADDOW A., ALEXANDER P. AN IMMUNOLOGICAL METHOD OF INCREASING THE SENSITIVITY OF PRIMARY SARCOMAS TO LOCAL IRRADIATION WITH X RAYS. Lancet. 1964 Feb 29;1(7331):452–457. doi: 10.1016/s0140-6736(64)90793-7. [DOI] [PubMed] [Google Scholar]
- Mathé G., Pouillart P., Lapeyraque F. Active immunotherapy of L1210 leukaemia applied after the graft of tumour cells. Br J Cancer. 1969 Dec;23(4):814–824. doi: 10.1038/bjc.1969.101. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Woodruff M. F., Boak J. L. Inhibitory effect of injection of Corynebacterium parvum on the growth of tumour transplants in isogenic hosts. Br J Cancer. 1966 Jun;20(2):345–355. doi: 10.1038/bjc.1966.42. [DOI] [PMC free article] [PubMed] [Google Scholar]