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. 1970 Sep;24(3):454–463. doi: 10.1038/bjc.1970.54

Antibody-producing Capacity in Human Cancer*

A K Y Lee, Merrill Rowley, I R Mackay
PMCID: PMC2008599  PMID: 5475752

Abstract

The antibody response to primary immunization with monomeric flagellin from Salmonella adelaide was studied in 61 patients with cancer and antibody-producing capacity was correlated with survival. In 27 patients suffering from “active” cancer, antibody-producing capacity was significantly depressed (P<0.05) as compared with sick but not cancerous controls; in 13 such patients who survived more than 6 months after immunization, antibody-producing capacity was moderately depressed, whereas in 14 who survived less than 6 months, the capacity was markedly depressed. In 34 patients with “cured” cancer, by surgery and/or radiotherapy, antibody-producing capacity was significantly greater than that of the “hospital” controls and patients with “active” cancer, but yet was significantly less than that of healthy subjects. Three explanations for the findings were considered: an immunodepressive effect of general debility, an immunodepressive effect specific to cancer and, on the other hand, the occurrence of cancer preferentially in individuals with an impaired capacity for antibody production. The present findings gained added relevance from recent evidence that a specific humoral immune response is evoked by antigens of certain types at least of human cancer.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ADA G. L., NOSSAL G. J., PYE J., ABBOT A. ANTIGENS IN IMMUNITY. I. PREPARATION AND PROPERTIES OF FLAGELLAR ANTIGENS FROM SALMONELLA ADELAIDE. Aust J Exp Biol Med Sci. 1964 Jun;42:267–282. [PubMed] [Google Scholar]
  2. BARR M., FAIRLEY G. H. Circulating antibodies in reticuloses. Lancet. 1961 Jun 17;1(7190):1305–1310. doi: 10.1016/s0140-6736(61)90237-9. [DOI] [PubMed] [Google Scholar]
  3. DEFENDI V., ROOSA R. A. EFFECT OF THYMECTOMY ON INDUCTION OF TUMORS AND ON THE TRANSPLANTABILITY OF POLYOMA-INDUCED TUMORS. Cancer Res. 1965 Apr;25:300–306. [PubMed] [Google Scholar]
  4. Dwyer J. M., Mackay I. R. Antigen-binding lymphocytes in human blood. Lancet. 1970 Jan 24;1(7639):164–167. doi: 10.1016/s0140-6736(70)90406-x. [DOI] [PubMed] [Google Scholar]
  5. GARDNER R. J., PRESTON F. W. Prolonged skin homograft survival in advanced cancer and cirrhosis of the liver. Surg Gynecol Obstet. 1962 Oct;115:399–402. [PubMed] [Google Scholar]
  6. LAMB D., PILNEY F., KELLY W. D., GOOD R. A. A comparative study of the incidence of anergy in patients with carcinoma, leukemia, hodgkin's disease and other lymphomas. J Immunol. 1962 Oct;89:555–558. [PubMed] [Google Scholar]
  7. LIBANSKY J. STUDY OF IMMUNOLOGIC REACTIVITY IN HEMOBLASTOSIS. CIRCULATING ANTIBODY FORMATION AS A RESPONSE TO ANTIGENIC STIMULUS IN LEUKEMIA, MALIGNANT LYMPHOMA, MYELOMA AND MYELOFIBROSIS. Blood. 1965 Feb;25:169–178. [PubMed] [Google Scholar]
  8. LOGAN J. The delayed type of allergic reaction in cancer: altered response to tuberculin and mumps virus. N Z Med J. 1956 Oct;55(309):408–410. [PubMed] [Google Scholar]
  9. MILLER J. F., GRANT G. A., ROE F. J. EFFECT OF THYMECTOMY ON THE INDUCTION OF SKIN TUMOURS BY 3,4-BENZOPYRENE. Nature. 1963 Aug 31;199:920–922. doi: 10.1038/199920a0. [DOI] [PubMed] [Google Scholar]
  10. Pollack W., Tripodi D. The role of the immune response in the establishment and rejection of neoplastic tissue. Int Arch Allergy Appl Immunol. 1967;32(5):429–435. doi: 10.1159/000229954. [DOI] [PubMed] [Google Scholar]
  11. Rowley M. J. "Natural" antibody in man to flagellar antigens of Salmonella adelaide. Aust J Exp Biol Med Sci. 1970 Apr;48(2):249–252. doi: 10.1038/icb.1970.26. [DOI] [PubMed] [Google Scholar]
  12. Solowey A. C., Rapaport F. T. Immunologic responses in cancer patients. Surg Gynecol Obstet. 1965 Oct;121(4):756–760. [PubMed] [Google Scholar]
  13. Southam C. M. The immunologic status of patients with nonlymphomatous cancer. Cancer Res. 1968 Jul;28(7):1433–1440. [PubMed] [Google Scholar]
  14. Thomson D. M., Krupey J., Freedman S. O., Gold P. The radioimmunoassay of circulating carcinoembryonic antigen of the human digestive system. Proc Natl Acad Sci U S A. 1969 Sep;64(1):161–167. doi: 10.1073/pnas.64.1.161. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Wistar R., Jr Serum antibody to Salmonella flagellar antigens. I. Methods of antibody assay. Aust J Exp Biol Med Sci. 1968 Dec;46(6):769–777. doi: 10.1038/icb.1968.183. [DOI] [PubMed] [Google Scholar]

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