Skip to main content
PMC home page
British Journal of Cancer logoLink to British Journal of Cancer
. 1970 Dec;24(4):843–848. doi: 10.1038/bjc.1970.99

The Structure of Tumours Derived from Mouse Cells after “Spontaneous” Transformation in vitro

L M Franks, F C Chesterman, C Rowlatt
PMCID: PMC2008703  PMID: 5533949

Abstract

The histological structure of 58 primary tumours derived from spontaneously transformed tissue culture cell lines from embryonic (14-16 days), young (3-20 days) and old (28-34 months) C3H and C57 mice is described. Although the cell lines were derived from a number of different organs the tumours were similar in morphology. The pattern was mixed, with “fibrosarcomatous”, “myxoid”, “epithelioid” and giant cell areas. The tumours resemble some types of haemangiopericytoma.

Full text

PDF
843

Images in this article

844-3Figs. 5-8
on p.844-3
844-5Fig. 9
on p.844-5
844-1Figs. 1-4
on p.844-1

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Allison A. C., Chesterman F. C., Baron S. Induction of tumors in adult hamsters with simian virus 40. J Natl Cancer Inst. 1967 Apr;38(4):567–572. [PubMed] [Google Scholar]
  2. Berman L. D. Comparative morphologic study of the virus-induced solid tumors of Syrian hamsters. J Natl Cancer Inst. 1967 Nov;39(5):847–901. [PubMed] [Google Scholar]
  3. CURRAN R. C., CRANE W. A. Mucopolysaccharides in the atheromatous aorta. J Pathol Bacteriol. 1962 Oct;84:405–412. doi: 10.1002/path.1700840214. [DOI] [PubMed] [Google Scholar]
  4. Chesterman F. C., Harvey J. J., Dourmashkin R. R., Salaman M. H. The pathology of tumors and other lesions induced in rodents by virus derived from a rat with Moloney leukemia. Cancer Res. 1966 Aug;26(8):1759–1768. [PubMed] [Google Scholar]
  5. Cornell R. Spontaneous neoplastic transformation in vitro: ultrastructure of transformed cell strains and tumors produced by injection of cell strains. J Natl Cancer Inst. 1969 Oct;43(4):891–906. [PubMed] [Google Scholar]
  6. DEFENDI V. Induction of tumours by polyoma in adult hamsters. Nature. 1960 Nov 5;188:508–509. doi: 10.1038/188508a0. [DOI] [PubMed] [Google Scholar]
  7. EDDY B. E., STEWART S. E., STANTON M. F., MARCOTTE J. M. Induction of tumors in rats by tissue-culture preparations of SE polyoma virus. J Natl Cancer Inst. 1959 Jan;22(1):161–171. [PubMed] [Google Scholar]
  8. Fullmer H. M. The histochemistry of the connective tissues. Int Rev Connect Tissue Res. 1965;3:1–76. doi: 10.1016/b978-1-4831-6753-4.50007-7. [DOI] [PubMed] [Google Scholar]
  9. Gordon H., Sweets H. H. A Simple Method for the Silver Impregnation of Reticulum. Am J Pathol. 1936 Jul;12(4):545–552.1. [PMC free article] [PubMed] [Google Scholar]
  10. HARRIS R. J., MALMGREN H., SYLVEN B. The polysaccharides of Rous sarcoma No. 1. Br J Cancer. 1954 Mar;8(1):141–146. doi: 10.1038/bjc.1954.11. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. LAW L. W., DUNN T. B., BOYLE P. J. Neoplasms in the C3H strain and in F1 hybrid mice of two crosses following introduction of extracts and filtrates of leukemic tissues. J Natl Cancer Inst. 1955 Oct;16(2):495–539. [PubMed] [Google Scholar]
  12. Murray M. R., Stout A. P. The glomus tumor: Investigation of its distribution and behavior, and the identity of its "epithelioid" cell. Am J Pathol. 1942 Mar;18(2):183–203. [PMC free article] [PubMed] [Google Scholar]
  13. SAXEN E. A. On the factor of age in the production of subcutaneous sarcomas in mice by 20-methylcholanthrene. J Natl Cancer Inst. 1953 Dec;14(3):547–569. [PubMed] [Google Scholar]
  14. SPICER S. S. DIAMINE METHODS FOR DIFFERENTIALING MUCOSUBSTANCES HISTOCHEMICALLY. J Histochem Cytochem. 1965 Mar;13:211–234. doi: 10.1177/13.3.211. [DOI] [PubMed] [Google Scholar]
  15. STANTON M. F., OTSUKA H. MORPHOLOGY OF THE ONCOGENIC RESPONSE OF HAMSTERS TO POLYOMA VIRUS INFECTION. J Natl Cancer Inst. 1963 Aug;31:365–409. [PubMed] [Google Scholar]
  16. STOUT A. P. Hemangiopericytoma; a study of 25 cases. Cancer. 1949 Nov;2(6):1027-54, illust. doi: 10.1002/1097-0142(194911)2:6<1027::aid-cncr2820020609>3.0.co;2-r. [DOI] [PubMed] [Google Scholar]
  17. Sobel H. Aging of connective tissue and molecular transport. Gerontologia. 1968;14(4):235–254. doi: 10.1159/000211663. [DOI] [PubMed] [Google Scholar]
  18. TODARO G. J., GREEN H. Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines. J Cell Biol. 1963 May;17:299–313. doi: 10.1083/jcb.17.2.299. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from British Journal of Cancer are provided here courtesy of Cancer Research UK

RESOURCES