Abstract
Until recently the public water supply to Worksop contained high concentrations of nitrate. An epidemiological study has revealed that, compared with low nitrate control towns, Worksop has an increased death rate from gastric cancer. The possible role of the bacterial production of nitrosamines in the aetiology of these stomach cancer deaths is discussed.
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- Asatoor A. M., Chamberlain M. J., Emmerson B. T., Johnson J. R., Levi A. J., Milne M. D. Metabolic effects of oral neomycin. Clin Sci. 1967 Aug;33(1):111–124. [PubMed] [Google Scholar]
- Brooks J. B., Cherry W. B., Thacker L., Alley C. C. Analysis by gas chromatography of amines and nitrosamines produced in vivo and in vitro by Proteus mirabilis. J Infect Dis. 1972 Aug;126(2):143–153. doi: 10.1093/infdis/126.2.143. [DOI] [PubMed] [Google Scholar]
- Correa P., Cuello C., Duque E. Carcinoma and intestinal metaplasia of the stomach in Colombian migrants. J Natl Cancer Inst. 1970 Feb;44(2):297–306. [PubMed] [Google Scholar]
- Druckrey H., Preussmann R., Ivankovic S., Schmähl D. Organotrope carcinogene Wirkungen bei 65 verschiedenen N-Nitroso-Verbindungen an BD-Ratten. Z Krebsforsch. 1967;69(2):103–201. [PubMed] [Google Scholar]
- Greenblatt M., Mirvish S., So B. T. Nitrosamine studies: induction of lung adenomas by concurrent administration of sodium nitrite and secondary amines in Swiss mice. J Natl Cancer Inst. 1971 May;46(5):1029–1034. [PubMed] [Google Scholar]
- Hawksworth G. M., Hill M. J. Bacteria and the N-nitrosation of secondary amines. Br J Cancer. 1971 Sep;25(3):520–526. doi: 10.1038/bjc.1971.66. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sander J., Schweinsberg F., Menz H. P. Untersuchungen über die Entstehung cancerogener Nitrosamine im Magen. Hoppe Seylers Z Physiol Chem. 1968 Dec;349(12):1691–1697. [PubMed] [Google Scholar]
- Savage W. E., Hajj S. N., Kass E. H. Demographic and prognostic characteristics of bacteriuria in pregnancy. Medicine (Baltimore) 1967 Sep;46(5):385–407. doi: 10.1097/00005792-196709000-00002. [DOI] [PubMed] [Google Scholar]