Abstract
Conversion of 7alpha3H-testosterone to 17beta-oestradiol by human mammary carcinoma tissue in vitro has been demonstrated. It was characterized unequivocally by conversion to 17beta-oestradiol-3-sulphate upon incubation with adenosine-3'-phosphate-5'-phosphosulphate and the highly specific enzyme oestrogen sulphotransferase.
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Selected References
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- Adams J. B., Low J. Enzymic synthesis of steroid sulphates. X. Isolation of oestrogen sulphotransferase from bovine placenta and comparison of its properties with adrenal oestrogen sulphotransferase. Biochim Biophys Acta. 1974 Nov 25;370(1):189–196. doi: 10.1016/0005-2744(74)90043-6. [DOI] [PubMed] [Google Scholar]
- Adams J. B., Poulos A. Enzymic synthesis of steroid sulphates. 3. Isolation and properties of estrogen sulphotransferase of bovine adrenal glands. Biochim Biophys Acta. 1967;146(2):493–508. doi: 10.1016/0005-2744(67)90233-1. [DOI] [PubMed] [Google Scholar]
- Dao T. L., Libby P. R. Conjugation of steroid hormones by normal and neoplastic tissues. J Clin Endocrinol Metab. 1968 Oct;28(10):1431–1439. doi: 10.1210/jcem-28-10-1431. [DOI] [PubMed] [Google Scholar]
- Jones D., Cameron E. H., Griffiths K., Gleave E. N., Forrest A. P. Steroid metabolism by human breast tumours. Biochem J. 1970 Mar;116(5):919–921. doi: 10.1042/bj1160919. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Miller W. R., Forrest A. P. Oestradiol synthesis by a human breast carcinoma. Lancet. 1974 Oct 12;2(7885):866–868. doi: 10.1016/s0140-6736(74)91202-1. [DOI] [PubMed] [Google Scholar]
- PAYNE A. H., MASON M. The enzymic synthesis of the sulfate esters of estradiol-17beta and diethylstilbesterol. Biochim Biophys Acta. 1963 Jun 4;71:719–724. doi: 10.1016/0006-3002(63)91146-6. [DOI] [PubMed] [Google Scholar]
- Rozhin J., Soderstrom R. L., Brooks S. C. Specificity studies on bovine adrenal estrogen sulfotransferase. J Biol Chem. 1974 Apr 10;249(7):2079–2087. [PubMed] [Google Scholar]