Abstract
The lethal effect of high-dose melphalan in mice could be offset by pretreatment with cyclophosphamide, cytosine arabinoside or low-dose melphalan. The reason for improved survival is unclear. Althoug animals given high-dose melphalan died with symptoms of gut death, in only one instance, that with low-dose melphalan itself, did pretreatment protect the intestinal epithelium as measured by the microcolony assay. A small enhancement in the recovery of the haemopoietic tissue in pretreated animals was noted, although this on its own is unlikely to explain the phenomenon. Experiments in tumour-bearing mice showed that pretreatment with cyclophosphamide did not reduce the toxicity of melphalan to the Lewis lung carcinoma.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Brecher G., Smith W. W., Wilson S., Fred S. Kinetics of colchicine-induced hemopoietic recovery in irradiated mice. Radiat Res. 1967 Mar;30(3):600–610. [PubMed] [Google Scholar]
- Hanks G. E., Ainsworth E. J. Endotoxin protection and colony-forming units. Radiat Res. 1967 Nov;32(3):367–382. [PubMed] [Google Scholar]
- Jeney A., Jr, Connors T. A., Jones M. The toxicity of merophan after pretreatment with subtoxic dose. Acta Physiol Acad Sci Hung. 1968;33(1):89–94. [PubMed] [Google Scholar]
- Millar J. L., Blackett N. M., Hudspith B. N. Enhanced post-irradiation recovery of the haemopoietic system in animals pretreated with a variety of cytotoxic agents. Cell Tissue Kinet. 1978 Sep;11(5):543–553. doi: 10.1111/j.1365-2184.1978.tb00826.x. [DOI] [PubMed] [Google Scholar]
- Millar J. L., Hudspith B. N., Blackett N. M. Reduced lethality in mice receiving a combined dose of cyclophosphamide and busulphan. Br J Cancer. 1975 Aug;32(2):193–198. doi: 10.1038/bjc.1975.149. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Millar J. L., Hudspith B. N. Sparing effect of cyclophosphamide (NSC-26271) pretreatment on animals lethally treated with gamma-irradiation. Cancer Treat Rep. 1976 Apr;60(4):409–414. [PubMed] [Google Scholar]
- Millar J. L., McElwain T. J. Combinations of cytotoxic agents that have less than expected toxicity on normal tissues in mice. Antibiot Chemother (1971) 1978;23:271–282. doi: 10.1159/000401490. [DOI] [PubMed] [Google Scholar]
- Rose W. C., Rimm A. A., Saltzstein E. C., Truitt R. L., Bortin M. M. Low-dose chemotherapy as a prelude to intensive treatment of spontaneous leukemia-lymphoma in AKR mice. J Natl Cancer Inst. 1975 Jul;55(1):219–221. doi: 10.1093/jnci/55.1.219. [DOI] [PubMed] [Google Scholar]
- Smith W. W., Wilson S. M. Effects of vinblastine and vincristine on survival and hemopoiesis in irradiated mice. J Natl Cancer Inst. 1967 Nov;39(5):1055–1066. [PubMed] [Google Scholar]
- Smith W. W., Wilson S. M., Fred S. S. Kinetics of stem cell depletion and proliferation: effects of vinblastine and vincristine in normal and irradiated mice. J Natl Cancer Inst. 1968 Apr;40(4):847–854. [PubMed] [Google Scholar]
- Steel G. G., Adams K. Stem-cell survival and tumor control in the Lewis lung carcinoma. Cancer Res. 1975 Jun;35(6):1530–1535. [PubMed] [Google Scholar]
- Stephens T. C., Peacock J. H. Tumour volume response, initial cell kill and cellular repopulation in B16 melanoma treated with cyclophosphamide and 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea. Br J Cancer. 1977 Sep;36(3):313–321. doi: 10.1038/bjc.1977.195. [DOI] [PMC free article] [PubMed] [Google Scholar]
- TILL J. E., McCULLOCH E. A. A direct measurement of the radiation sensitivity of normal mouse bone marrow cells. Radiat Res. 1961 Feb;14:213–222. [PubMed] [Google Scholar]
- Withers H. R., Elkind M. M. Microcolony survival assay for cells of mouse intestinal mucosa exposed to radiation. Int J Radiat Biol Relat Stud Phys Chem Med. 1970;17(3):261–267. doi: 10.1080/09553007014550291. [DOI] [PubMed] [Google Scholar]