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. 1978 Sep;38(3):411–417. doi: 10.1038/bjc.1978.222

Oncogenic transformation in vitro by the hypoxic cell sensitizer misonidazole.

R C Miller, E J Hall
PMCID: PMC2009745  PMID: 708572

Abstract

The hypoxic cell sensitizer Misonidazole (Ro-07-0582) induces oncogenic transformations in the C3H/10T1/2 mouse embryo cell line cultured in vitro. A drug concentration of 0.4 mM applied to aerated cells for 3 or 6 days results in a transformation rate comparable to that observed following an X-ray dose of 1 Gray. A higher drug concentration of 6.0 mM is equivalent to 4 Gy. The combination of Misonidazole and X-rays produces a significant increase in the frequency of transformation over either drug or radiation alone, but the data are equivocal on the question of additivity vs synergism.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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