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. 1979 Jun;39(6):773–778. doi: 10.1038/bjc.1979.131

Lipid peroxidation of the microsomal fraction and extracted microsomal lipids from DAB-induced hepatomas.

T J Player, D J Mills, A A Horton
PMCID: PMC2009979  PMID: 109113

Abstract

NADPH- and ascorbic acid-induced microsomal lipid peroxidation was almost absent in subcutaneously implanted DAB-induced hepatomas D23, D30 and D192A, and present at greatly reduced levels in DAB-induced primary hepatomas when compared with normal liver controls. Fatty acid analysis of the microsomal lipid from passaged tumours demonstrated adequate levels of substrate in the phospholipid fractions to support lipid peroxidation. Lipid extracted from hepatoma microsomal fractions was shown to undergo ascorbic acid-induced lipid peroxidation, but to a lesser extent that the corresponding liver extract. This may be partially explained by a decrease in the phospholipid content of hepatoma microsomal membranes. However, phospholipid extracted from microsomal fractions of hepatoma and liver supported lipid peroxidation to a similar extent. The possible role of the non-lipid component of the membrane in the process of lipid peroxidation is discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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