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. 1979 Nov;40(5):710–718. doi: 10.1038/bjc.1979.251

Tumour markers in breast cancer.

D H Cove, K L Woods, S C Smith, D Burnett, J Leonard, R J Grieve, A Howell
PMCID: PMC2010109  PMID: 92331

Abstract

The clinical usefulness of 8 potential tumour markers has been evaluated in 69 patients with Stage I and II breast cancer and 57 patients with Stage III and IV. Serum CEA concentrations were raised in 13% of patients with local and 65% of those with advanced breast cancer. In patients with clinical evidence of progression or regression of tumour, serum CEA levels changed appropriately in 83% of cases. Taking 4 of the markers (carcinoembryonic antigen (CEA), lactalbumin, alpha subunit and haptoglobin) serum concentrations of one or more were raised in 33% of patients with local disease and 81% of those with advanced breast cancer. However, marker concentrations were often only marginally raised, and are unlikely to provide sensitive guide to tumour burden. CEA, lactalbumin and alpha subunit were detectable in 68%, 43% and 40% respectively of extracts of primary breast cancers.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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