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. 1979 Dec;40(6):839–847. doi: 10.1038/bjc.1979.274

Immunoreactivity by intrinsic lymphoid cells in colorectal carcinoma.

J A Werkmeister, E Pihl, A P Nind, G R Flannery, R C Nairn
PMCID: PMC2010150  PMID: 316708

Abstract

Mononuclear leucocytes were separated by Hypaque--Ficoll from 60 unselected primary colorectal carcinomas, and then fractionated by rosetting with sheep erythrocytes, either alone (E) or coated with antibody and complement (EAC). The E-rosetting cells, putative T lymphocytes, were cytotoxic in vitro to autologous tumour cells in 18 of the 60 cases, whilst the EAC-rosetting cells were unreactive. This intrinsic T-lymphocyte anti-tumour immunoreactivity was significantly associated with the presence of "cuffs" of small dark lymphocytes at the mesocolic or pararectal edge of the primary tumours, but there was no correlation with antitumour cytotoxic lymphocytes in the patient's blood at the time of operation.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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