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. 1980 Apr;41(4):587–592. doi: 10.1038/bjc.1980.101

Serum sialic acid and CEA concentrations in human breast cancer.

A Hogan-Ryan, J J Fennelly, M Jones, B Cantwell, M J Duffy
PMCID: PMC2010272  PMID: 7387856

Abstract

The concentration of bound sialic acid in the sera of 56 normal subjects and 65 subjects with breast cancer was measured, in order to determine (1) whether serum sialic acid concentrations are raised in breast cancer and (2) whether the concentration of sialic acid in serum reflects tumour stage. The amount of sialic acid in serum was compared to serum carcinoembryonic antigen (CEA) values. Urinary hydroxyproline and serum alkaline phosphatase concentrations were used as indicators of bone and liver involvement. Erythrocyte sedimentation rate (ESR) was also measured. Significantly elevated serum sialic acid concentrations were found in breast cancer, and showed correlation with tumour stage. Serum sialic acid values did not correlate with CEA values. The results suggest that measurement of serum sialic acid concentrations may be of adjunctive value in assessing tumour stage.

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Selected References

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  1. Bradley W. P., Blasco A. P., Weiss J. F., Alexander J. C., Jr, Silverman N. A., Chretien P. B. Correlations among serum protein-bound carbohydrates, serum glycoproteins, lymphocyte reactivity, and tumors burden in cancer patients. Cancer. 1977 Nov;40(5):2264–2272. doi: 10.1002/1097-0142(197711)40:5<2264::aid-cncr2820400537>3.0.co;2-3. [DOI] [PubMed] [Google Scholar]
  2. Coombes R. C., Powles T. J., Gazet J. C., Ford H. T., Nash A. G., Sloane J. P., Hillyard C. J., Thomas P., Keyser J. W., Marcus D. A biochemical approach to the staging of human breast cancer. Cancer. 1977 Aug;40(2):937–944. doi: 10.1002/1097-0142(197708)40:2<937::aid-cncr2820400252>3.0.co;2-d. [DOI] [PubMed] [Google Scholar]
  3. Gray B. N., Kopito R. R., Anderson L. L., Baralt O. L., Connery C. K., Watkins E., Jr Sialoproteinaemia: lack of correlation with inhibition of in vitro lymphoblastosis induced by phytohaemagglutinin or alloantigen. Clin Exp Immunol. 1976 Aug;25(2):227–233. [PMC free article] [PubMed] [Google Scholar]
  4. MCNEIL C., BERRETT C. R., SU L. Y., TRENTELMAN E. F., HELMICK W. M. SIALIC ACID AS A MEASURE OF SERUM MUCOPROTEINS. Am J Clin Pathol. 1965 Feb;43:130–133. doi: 10.1093/ajcp/43.2.130. [DOI] [PubMed] [Google Scholar]
  5. Mrochek J. E., Dinsmore S. R., Tormey D. C., Waalkes T. P. Protein-bound carbohydrates in breast cancer. Liquid-chromatographic analysis for mannose, galactose, fucose, and sialic acid in serum. Clin Chem. 1976 Sep;22(9):1516–1521. [PubMed] [Google Scholar]
  6. Powles T. J., Rosset G., Leese C. L., Bondy P. K. Early morning hydroxyproline excretion in patients with breast cancer. Cancer. 1976 Dec;38(6):2564–2566. doi: 10.1002/1097-0142(197612)38:6<2564::aid-cncr2820380648>3.0.co;2-w. [DOI] [PubMed] [Google Scholar]
  7. Reed R. C., Gutterman J. U., Mavlight G. M., Hersh E. M. Sialic acid on leukemia cells: relation to morphology and tumor immunity. Proc Soc Exp Biol Med. 1974 Mar;145(3):790–793. doi: 10.3181/00379727-145-37896. [DOI] [PubMed] [Google Scholar]
  8. SAIFER A., GERSTENFELD S. Photometric determination of sialic acids in serum and cerebrospinal fluid with the thiobarbituric acid method. Clin Chim Acta. 1962 Jul;7:467–475. doi: 10.1016/0009-8981(62)90086-4. [DOI] [PubMed] [Google Scholar]
  9. Silver H. K., Rangel D. M., Morton D. L. Serum sialic acid elevations in malignant melanoma patients. Cancer. 1978 Apr;41(4):1497–1499. doi: 10.1002/1097-0142(197804)41:4<1497::aid-cncr2820410438>3.0.co;2-9. [DOI] [PubMed] [Google Scholar]
  10. Simmons R. L., Rios A. Cell surface modification in the treatment of experimental cancer: neuraminidase or concanavalin A. Cancer. 1974 Oct;34(4 Suppl):suppl–suppl:1547. doi: 10.1002/1097-0142(197410)34:8+<1541::aid-cncr2820340828>3.0.co;2-g. [DOI] [PubMed] [Google Scholar]
  11. Simmons R. L., Rios A., Lundgren G., Ray P. K., McKhann C. F., Haywood G. R. Immunospecific regression of methylcholanthrene fibrosarcoma with the use of neuraminidase. Surgery. 1971 Jul;70(1):38–46. [PubMed] [Google Scholar]
  12. Tormey D. C., Waalkes T. P., Simon R. M. Biological markers in breast carcinoma. II. Clinical correlations with human chorionic gonadotrophin. Cancer. 1977 Jun;39(6):2391–2396. doi: 10.1002/1097-0142(197706)39:6<2391::aid-cncr2820390613>3.0.co;2-7. [DOI] [PubMed] [Google Scholar]
  13. WARREN L. The thiobarbituric acid assay of sialic acids. J Biol Chem. 1959 Aug;234(8):1971–1975. [PubMed] [Google Scholar]
  14. Warren L., Fuhrer J. P., Buck C. A. Surface glycoproteins of normal and transformed cells: a difference determined by sialic acid and a growth-dependent sialyl transferase. Proc Natl Acad Sci U S A. 1972 Jul;69(7):1838–1842. doi: 10.1073/pnas.69.7.1838. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Watkins E., Jr, Gray B. N., Anderson L. L., Baralt O. L., Nebril L. R., Waters M. F., Connery C. K. Neuraminidase-mediated augmentation of in vitro immune response of patients with solid tumors. Int J Cancer. 1974 Dec 15;14(6):799–807. doi: 10.1002/ijc.2910140614. [DOI] [PubMed] [Google Scholar]

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