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. 1980 Aug;42(2):284–291. doi: 10.1038/bjc.1980.228

Prognostic effect of early diagnostic splenectomy in Hodgkin's disease: a randomized trial.

J Askergren, M Björkholm, G Holm, B Johansson, H Mellstedt, R Sundblad, G Söderberg
PMCID: PMC2010376  PMID: 7426335

Abstract

A randomized trial is reported which evaluates the effect of early diagnostic splenectomy on the prognosis of patients with Hodgkin's disease (HD) and uncertain prognosis. This was started in January 1973 and concluded in April 1979. Sixty-seven patients were entered in the study and 31 were randomized for splenectomy. All patients except 2 received total nodal irradiation, excluding the splenic and hepatic areas. After 40 months' observation there was no difference between the groups in respect of survival and the number of recurrences. However, relapses occurred earlier in the splenectomized patients. Pneumococcal septicaemia was recorded in 2 splenectomized patients. It is concluded that prognosis is not improved by diagnostic splenectomy in HD patients with uncertain prognosis and treated with total nodal irradiation.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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