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. 1981 Feb;43(2):177–182. doi: 10.1038/bjc.1981.26

A case-control study of head and neck cancer in the Republic of Ireland.

B Herity, M Moriarty, G J Bourke, L Daly
PMCID: PMC2010510  PMID: 7470380

Abstract

A retrospective case-control study of 200 patients with head and neck cancer, and 200 controls matched for age and sex, confirmed the importance of tobacco and alcohol consumption in the aetiology of malignant tumours of the upper gastrointestinal and upper respiratory tracts. A male-female ratio of 3:1 was found, and the association of smoking with laryngeal cancer and of alcohol with cancer of the tongue was particularly strong. A significant excess of alcohol-related occupations was found among the cases. These findings are discussed.

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Selected References

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  1. Breslow N. E., Enstrom J. E. Geographic correlations between cancer mortality rates and alcohol-tobacco consumption in the United States. J Natl Cancer Inst. 1974 Sep;53(3):631–639. doi: 10.1093/jnci/53.3.631. [DOI] [PubMed] [Google Scholar]
  2. Dean G., MacLennan R., McLoughlin H., Shelley E. Causes of death of blue-collar workers at a Dublin brewery, 1954--73. Br J Cancer. 1979 Oct;40(4):581–589. doi: 10.1038/bjc.1979.223. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Feldman J. G., Hazan M. A case-control investigation of alcohol, tobacco, and diet in head and neck cancer. Prev Med. 1975 Dec;4(4):444–463. doi: 10.1016/0091-7435(75)90032-8. [DOI] [PubMed] [Google Scholar]
  4. Hinds M. W., Thomas D. B., O'Reilly H. P. Asbestos, dental X-rays, tobacco, and alcohol in the epidemiology of laryngeal cancer. Cancer. 1979 Sep;44(3):1114–1120. doi: 10.1002/1097-0142(197909)44:3<1114::aid-cncr2820440346>3.0.co;2-e. [DOI] [PubMed] [Google Scholar]
  5. Jayant K., Balakrishnan V., Sanghvi L. D., Jussawalla D. J. Quantification of the role of smoking and chewing tobacco in oral, pharyngeal, and oesophageal cancers. Br J Cancer. 1977 Feb;35(2):232–235. doi: 10.1038/bjc.1977.31. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. MANTEL N., HAENSZEL W. Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst. 1959 Apr;22(4):719–748. [PubMed] [Google Scholar]
  7. Martínez I. Retrospective and prospective study of carcinoma of the esophagus, mouth, and pharynx in Puerto Rico. Bol Asoc Med P R. 1970 Jun;62(6):170–178. [PubMed] [Google Scholar]
  8. McMichael A. J. Increases in laryngeal cancer in Britain and Australia in relation to alcohol and tobacco consumption trends. Lancet. 1978 Jun 10;1(8076):1244–1247. doi: 10.1016/s0140-6736(78)92477-7. [DOI] [PubMed] [Google Scholar]
  9. Rothman K. J. Synergy and antagonism in cause-effect relationships. Am J Epidemiol. 1974 Jun;99(6):385–388. doi: 10.1093/oxfordjournals.aje.a121626. [DOI] [PubMed] [Google Scholar]
  10. Rothman K. J. The estimation of synergy or antagonism. Am J Epidemiol. 1976 May;103(5):506–511. doi: 10.1093/oxfordjournals.aje.a112252. [DOI] [PubMed] [Google Scholar]
  11. Rothman K., Keller A. The effect of joint exposure to alcohol and tobacco on risk of cancer of the mouth and pharynx. J Chronic Dis. 1972 Dec;25(12):711–716. doi: 10.1016/0021-9681(72)90006-9. [DOI] [PubMed] [Google Scholar]
  12. Simarak S., de Jong U. W., Breslow N., Dahl C. J., Ruckphaopunt K., Scheelings P., Maclennan R. Cancer of the oral cavity, pharynx/larynx and lung in North Thailand: case-control study and analysis of cigar smoke. Br J Cancer. 1977 Jul;36(1):130–140. doi: 10.1038/bjc.1977.163. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. VINCENT R. G., MARCHETTA F. THE RELATIONSHIP OF THE USE OF TOBACCO AND ALCOHOL TO CANCER OF THE ORAL CAVITY, PHARYNX OR LARYNX. Am J Surg. 1963 Sep;106:501–505. doi: 10.1016/0002-9610(63)90137-5. [DOI] [PubMed] [Google Scholar]
  14. WYNDER E. L., BROSS I. J., DAY E. A study of environmental factors in cancer of the larynx. Cancer. 1956 Jan-Feb;9(1):86–110. doi: 10.1002/1097-0142(195601/02)9:1<86::aid-cncr2820090108>3.0.co;2-6. [DOI] [PubMed] [Google Scholar]
  15. WYNDER E. L., BROSS I. J., FELDMAN R. M. A study of the etiological factors in cancer of the mouth. Cancer. 1957 Nov-Dec;10(6):1300–1323. doi: 10.1002/1097-0142(195711/12)10:6<1300::aid-cncr2820100628>3.0.co;2-2. [DOI] [PubMed] [Google Scholar]
  16. Wynder E. L., Chan P. C. The possible role of riboflavin deficiency in epithelial neoplasia. II. Effect of skin tumor development. Cancer. 1970 Dec;26(6):1221–1224. doi: 10.1002/1097-0142(197012)26:6<1221::aid-cncr2820260607>3.0.co;2-i. [DOI] [PubMed] [Google Scholar]
  17. Wynder E. L., Covey L. S., Mabuchi K., Mushinski M. Environmental factors in cancer of the larynx: a second look. Cancer. 1976 Oct;38(4):1591–1601. doi: 10.1002/1097-0142(197610)38:4<1591::aid-cncr2820380425>3.0.co;2-r. [DOI] [PubMed] [Google Scholar]
  18. Wynder E. L., Mabuchi K. Cancer of the gastrointestinal tract. Etiological and environmental factors. JAMA. 1973 Dec 24;226(13):1546–1548. doi: 10.1001/jama.226.13.1546. [DOI] [PubMed] [Google Scholar]

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