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. 1981 Mar;43(3):324–329. doi: 10.1038/bjc.1981.51

Childhood leukaemia in North West England 1954-1977: epidemiology, incidence and survival.

J M Birch, R Swindell, H B Marsden, P H Morris Jones
PMCID: PMC2010613  PMID: 6939448

Abstract

The annual incidence of leukaemia among children aged up to 14 years as estimated by the Manchester Children's Tumour Registry has been analysed for the 24 years 1954-1977. A significant increase in acute lymphoid leukaemia (ALL) was found, while the incidence of acute myeloid leukaemia (AML) remained constant. Other types of leukaemia were too rare to be analysed separately. The increase in ALL was concentrated among boys in the 1--5-year age group. Analysis with respect to initial white-cell count showed the increase to be more pronounced in children with initial white cell counts of 1-5 x 10(4)/microliters. The proportion of cases presenting in Lancashire compared with Greater Manchester did not change during the study period. The distribution of cases with respect to social class and socio-economic group of the parents also remained constant. Due to advances in the treatment of childhood ALL survival improved considerably during the study period and no increase in mortality was seen.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Birch J. M., Marsden H. B., Swindell R. Acute lymphoid leukaemia of childhood in North-West England. Lancet. 1979 Oct 20;2(8147):854–855. doi: 10.1016/s0140-6736(79)92208-6. [DOI] [PubMed] [Google Scholar]
  2. Birch J. M., Marsden H. B., Swindell R. Incidence of malignant disease in childhood: a 24-year review of the Manchester Children's Tumour Registry data. Br J Cancer. 1980 Aug;42(2):215–223. doi: 10.1038/bjc.1980.221. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Chaput de Saintonge D. M., Vere D. W. Why don't doctors use cusums? Lancet. 1974 Jan 26;1(7848):120–121. doi: 10.1016/s0140-6736(74)92345-9. [DOI] [PubMed] [Google Scholar]
  4. Ericsson J. L., Karnström L., Mattsson B. Childhood cancer in Sweden, 1958-1974. I. Incidence and mortality. Acta Paediatr Scand. 1978 Jul;67(4):425–432. doi: 10.1111/j.1651-2227.1978.tb16349.x. [DOI] [PubMed] [Google Scholar]
  5. Kumar S., Carr T. F., Evans D. I., Morris-Jones P., Hann I. M. Prognostic significance of cell surface markers in childhood acute lymphoblastic leukaemia. Clin Lab Haematol. 1979;1(2):121–128. doi: 10.1111/j.1365-2257.1979.tb00459.x. [DOI] [PubMed] [Google Scholar]
  6. Leck I., Birch J. M., Marsden H. B., Steward J. K. Methods of classifying and ascertaining children's tumours. Br J Cancer. 1976 Jul;34(1):69–82. doi: 10.1038/bjc.1976.124. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Li F. P., Jin F., Tu C. T., Gao Y. T. Incidence of childhood leukemia in Shanghai. Int J Cancer. 1980 Jun 15;25(6):701–703. doi: 10.1002/ijc.2910250603. [DOI] [PubMed] [Google Scholar]
  8. Shaw M. T. The cytochemistry of acute leukemia: a diagnostic and prognostic evaluation. Semin Oncol. 1976 Sep;3(3):219–228. [PubMed] [Google Scholar]
  9. Teppo L., Salonen T., Hakulinen T. Incidence of childhood cancer in Finland. J Natl Cancer Inst. 1975 Nov;55(5):1065–1067. doi: 10.1093/jnci/55.5.1065. [DOI] [PubMed] [Google Scholar]
  10. Young J. L., Jr, Miller R. W. Incidence of malignant tumors in U. S. children. J Pediatr. 1975 Feb;86(2):254–258. doi: 10.1016/s0022-3476(75)80484-7. [DOI] [PubMed] [Google Scholar]

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