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British Journal of Cancer logoLink to British Journal of Cancer
. 1981 May;43(5):684–688. doi: 10.1038/bjc.1981.99

Increased tissue histamine in tumour-bearing mice and rats.

C Burtin, P Scheinmann, J C Salomon, G Lespinats, C Frayssinet, B Lebel, P Canu
PMCID: PMC2010678  PMID: 7248152

Abstract

Tissue histamine levels were studied in C3H and C57BL/6 mice bearing a methylcholanthrene-induced fibrosarcoma, in Wag rats bearing an aflatoxin B1-induced hepatoma, and in Commentry rats bearing a grafted hepatoma. Histamine levels were significantly higher (1.5 to 3 fold) in the tumour-bearing animals for ventral and dorsal skin, skeletal muscle and stomach fundus. Total histamine content was increased in the spleen. In C3H mice with McC3-1 fibrosarcoma, the excision of the tumour or its partial regression by intratumoral injections of corynebacterium parvum induced a reversion to normal values. The tumour thus appears responsible for the increased histamine levels in tissues distant from the tumour.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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