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. 1981 May;43(5):637–643. doi: 10.1038/bjc.1981.94

Peculiarities of hyperlipidaemia in tumour patients.

V M Dilman, L M Berstein, M N Ostroumova, Y V Tsyrlina, A G Golubev
PMCID: PMC2010684  PMID: 7248149

Abstract

The study group included 684 cases: 258 patients with breast carcinoma, 113 males with lung cancer, 42 patients with rectal tumours, 42 patients with stomach tumours, 59 patients with fibroadenomatosis, and 170 healthy subjects of varying age (male and female). A relatively high blood triglyceride level was found in patients with breast, lung, rectal (females), and stomach (female) tumours. The blood concentration of high-density lipoprotein-cholesterol in patients with breast, lung, and stomach (female) tumours was relatively low. The elimination of tumour (breast carcinoma) did not lead to significant changes in lipid metabolism. There was no correlation between degree of lipidaemia and stage of tumour progression except in the cases of rectal cancer. Preliminary results are presented on the tentative classification of hyperlipoproteinaemia in tumour patients, using the lipid concentration threshold values advocated by Carlson et al. (1977); an increased frequency of Type IV hyperlipoproteinaemia proved to be the most characteristic feature of tumour patients. The results are discussed in terms of the concept of the importance of lipid metabolic disturbances, primarily those due to ageing, in the genesis of the syndrome of "cancerophilia" (predisposition to cancer).

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Barclay M., Skipski V. P. Lipoproteins in relation to cancer. Prog Biochem Pharmacol. 1975;10:76–111. [PubMed] [Google Scholar]
  2. Barclay M., Skipski V. P., Terebus-Kekish O., Greene E. M., Kaufman R. J., Stock C. C. Effects of cancer upon high-density and other lipoproteins. Cancer Res. 1970 Sep;30(9):2420–2430. [PubMed] [Google Scholar]
  3. CARLSON L. A. DETERMINATION OF SERUM TRIGLYCERIDES. J Atheroscler Res. 1963 Jul-Aug;3:334–336. doi: 10.1016/s0368-1319(63)80012-5. [DOI] [PubMed] [Google Scholar]
  4. Carlson L. A., Danielson M., Ekberg I., Klintemar B., Rosenhamer G. Reduction of myocardial reinfarction by the combined treatment with clofibrate and nicotinic acid. Atherosclerosis. 1977 Sep;28(1):81–86. doi: 10.1016/0021-9150(77)90201-5. [DOI] [PubMed] [Google Scholar]
  5. Chao F. C., Efron B., Wolf P. The possible prognostic usefulness of assessing serum proteins and cholesterol in malignancy. Cancer. 1975 Apr;35(4):1223–1229. doi: 10.1002/1097-0142(197504)35:4<1223::aid-cncr2820350429>3.0.co;2-t. [DOI] [PubMed] [Google Scholar]
  6. Chen H. W., Kandutsch A. A., Heiniger H. J. The role of cholesterol in malignancy. Prog Exp Tumor Res. 1978;22:275–316. doi: 10.1159/000401203. [DOI] [PubMed] [Google Scholar]
  7. Chen R. M., Getz G. S., Fischer-Dzoga K., Wissler R. W. The role of hyperlipidemic serum on the proliferation and necrosis of aortic medial cells in vitro. Exp Mol Pathol. 1977 Jun;26(3):359–374. doi: 10.1016/0014-4800(77)90039-9. [DOI] [PubMed] [Google Scholar]
  8. Dilman V. M. Ageing, metabolic immunodepression and carcinogenesis. Mech Ageing Dev. 1978 Sep;8(3):153–173. doi: 10.1016/0047-6374(78)90015-5. [DOI] [PubMed] [Google Scholar]
  9. Dilman V. M., Berstein L. M., Bobrov Y. F., Bohman Y. V., Kovaleva I. G., Krylova N. V. Hypothalamopituitary hyperactivity and endometrial carcinoma. Qualitative and quantitative disturbances in hormone production. Am J Obstet Gynecol. 1968 Nov 15;102(6):880–889. doi: 10.1016/0002-9378(68)90517-6. [DOI] [PubMed] [Google Scholar]
  10. Dilman V. M. Hypothalamic mechanisms of ageing and of specific age pathology--V. A model for the mechanism of human specific age pathology and natural death. Exp Gerontol. 1979;14(6):287–300. doi: 10.1016/0531-5565(79)90040-8. [DOI] [PubMed] [Google Scholar]
  11. Dilman V. M. Metabolic immunodepression which increases the risk of cancer. Lancet. 1977 Dec 10;2(8050):1207–1209. doi: 10.1016/s0140-6736(77)90442-1. [DOI] [PubMed] [Google Scholar]
  12. Eisenberg S., Levy R. I. Lipoprotein metabolism. Adv Lipid Res. 1975;13:1–89. [PubMed] [Google Scholar]
  13. Feldman E. B., Carter A. C. Circulating lipids and lipoproteins in women with metastatic breast carcinoma. J Clin Endocrinol Metab. 1971 Jul;33(1):8–13. doi: 10.1210/jcem-33-1-8. [DOI] [PubMed] [Google Scholar]
  14. Havel R. J., Kane J. P., Balasse E. O., Segel N., Basso L. V. Splanchnic metabolism of free fatty acids and production of triglycerides of very low density lipoproteins in normotriglyceridemic and hypertriglyceridemic humans. J Clin Invest. 1970 Nov;49(11):2017–2035. doi: 10.1172/JCI106422. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. LEDVINA M., COUFALOVA S. The serum beta-lipoprotein level in tumours. Neoplasma. 1960;7:419–426. [PubMed] [Google Scholar]
  16. Liebelt R. A., Liebelt A. G., Johnston H. M. Lipid mobilization and food intake in experimentally obese mice bearing transplanted tumors. Proc Soc Exp Biol Med. 1971 Nov;138(2):482–490. doi: 10.3181/00379727-138-35924. [DOI] [PubMed] [Google Scholar]
  17. Littman M. L., Taguchi T., Mosbach E. H. Effect of cholesterol-free, fat-free diet and hypocholesteremic agents on growth of transplantable animal tumors. Cancer Chemother Rep. 1966 Jan-Feb;50(1):25–45. [PubMed] [Google Scholar]
  18. MILLER B. J., ERF L. The serum proteins and lipoproteins in patients with carcinoma and in subjects free of recurrence. Surg Gynecol Obstet. 1956 Apr;102(4):487–491. [PubMed] [Google Scholar]
  19. Meade C. J., Mertin J. Fatty acids and immunity. Adv Lipid Res. 1978;16:127–165. doi: 10.1016/b978-0-12-024916-9.50008-1. [DOI] [PubMed] [Google Scholar]
  20. Olefsky J., Farquhar J. W., Reaven G. M. Sex difference in the kinetics of triglyceride metabolism in normal and hypertriglyceridaemic human subjects. Eur J Clin Invest. 1974 Apr;4(2):121–127. doi: 10.1111/j.1365-2362.1974.tb00382.x. [DOI] [PubMed] [Google Scholar]
  21. Quarfordt S. H., Frank A., Shames D. M., Berman M., Steinberg D. Very low density lipoprotein triglyceride transport in type IV hyperlipoproteinemia and the effects of carbohydrate-rich diets. J Clin Invest. 1970 Dec;49(12):2281–2297. doi: 10.1172/JCI106448. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Rifkind B. Typing of hyperlipoproteinaemias. Atherosclerosis. 1970 May-Jun;11(3):545–546. doi: 10.1016/0021-9150(70)90032-8. [DOI] [PubMed] [Google Scholar]
  23. Rose G., Blackburn H., Keys A., Taylor H. L., Kannel W. B., Paul O., Reid D. D., Stamler J. Colon cancer and blood-cholesterol. Lancet. 1974 Feb 9;1(7850):181–183. doi: 10.1016/s0140-6736(74)92492-1. [DOI] [PubMed] [Google Scholar]
  24. Rose G., Shipley M. J. Plasma lipids and mortality: a source of error. Lancet. 1980 Mar 8;1(8167):523–526. doi: 10.1016/s0140-6736(80)92775-0. [DOI] [PubMed] [Google Scholar]
  25. Smethurst M., Basu T. K., Williams D. C. Levels of cholesterol, 11-hydroxycorticosteroids and progesterone in plasma from postmenopausal women with breast cancer. Eur J Cancer. 1975 Oct;11(10):751–755. doi: 10.1016/0014-2964(75)90051-1. [DOI] [PubMed] [Google Scholar]
  26. Tsyrlina E. V., Bershtein L. M., Semiglazov V. F., Vasilieva I. A., Kholdin S. A., Dilman V. M. Endocrine-metabolic criteria for distinguishing two pathogenetic types of breast cancer. Neoplasma. 1977;24:199–206. [PubMed] [Google Scholar]
  27. Westlund K., Nicolaysen R. Ten-year mortality and morbidity related to serum cholesterol. A follow-up of 3.751 men aged 40-49. Scand J Clin Lab Invest Suppl. 1972;127:1–24. [PubMed] [Google Scholar]

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