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. 1981 May;43(5):696–700. doi: 10.1038/bjc.1981.101

Human monoclonal antibodies to lung-cancer antigens.

K Sikora, R Wright
PMCID: PMC2010695  PMID: 7248154

Abstract

Lymphocytes obtained from hilar and bronchial lymph nodes from 23 patients undergoing radical surgery for carcinoma of the bronchus were fused with established rat or mouse myeloma lines. 62% of the resultant hybrids were found to be secreting human Ig detected by a sensitive staphylococcal Protein A-coupled SRBC assay. Immunoglobulins synthesized by such hybrids were internally labelled with 3H-lysine and their antibody activity against a variety of membrane preparations determined. Nine monoclonal antibodies were found which bound to molecules on lung-cancer membranes and not on normal lung membranes from the same patient.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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