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. 1981 Jun;43(6):767–771. doi: 10.1038/bjc.1981.114

Plasma prostaglandins in mucositis due to radiotherapy and chemotherapy for head and neck cancer.

N S Tanner, I F Stamford, A Bennett
PMCID: PMC2010698  PMID: 7248158

Abstract

Patients with head and neck cancer were treated with synchronous radiotherapy and chemotherapy (vincristine, bleomycin and methotrexate). Before treatment, mucositis was absent and low amounts of prostaglandin-like material were extracted from peripheral plasma. As treatment proceeded mucositis occurred, and its degree correlated with the amount of prostaglandin-like material extracted from the plasma. Some patients were given moderate doses of drugs which inhibit prostaglandin synthesis, but mucositis still occurred.

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Selected References

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