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. 1981 Nov;44(5):628–636. doi: 10.1038/bjc.1981.247

Multiple primary cancers of the breast and ovary.

P Prior, J A Waterhouse
PMCID: PMC2010853  PMID: 7317267

Abstract

Multiple primary cancer of the breast and ovary were investigated as part of a survey being undertaken at the Birmingham and West Midlands Regional Cancer Registry. Population-based data relating to 17,756 registrations for breast and 3470 for ovarian cancer between 1950 and 1964 were analysed. On the basis of person-years at risk and incidence rates for the Region (1960-1962), an increased risk of a second primary tumour in the ovary was observed in patients diagnosed with a first primary in the breast before 45 years of age (O = 8; E = 1.83; P less than 0.001). No excess was found in patients diagnosed after 45 years of age (O = 15; E = 17.06). In patients with an index tumour of the ovary, the observed number of second primary tumours of the breast was not significantly different from the expected number (O = 19; E = 12.95). Complementary analysis (a combined assessment for the 2 sites) showed that the development of a first primary at either site before 45 years of age carried a 2.8-fold risk of a second primary tumour at the other site (O = 9; E = 3.21; P less than 0.01). After 45 years of age no increased risk was found (O = 32; E = 28.63). Over all ages a 1.3-fold risk was observed (O = 42; E = 31.54; P less than 0.05). No evidence of subfertility was found in the 9 patients in the high-risk premenopausal group who developed the 2 tumours. The results are more consistent with an aetiology of early exposure to an external carcinogen than with one of abnormal hormone production.

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Selected References

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  1. Bulbrook R. D., Hayward J. L., Spicer C. C. Relation between urinary androgen and corticoid excretion and subsequent breast cancer. Lancet. 1971 Aug 21;2(7721):395–398. doi: 10.1016/s0140-6736(71)90113-9. [DOI] [PubMed] [Google Scholar]
  2. Casagrande J. T., Louie E. W., Pike M. C., Roy S., Ross R. K., Henderson B. E. "Incessant ovulation" and ovarian cancer. Lancet. 1979 Jul 28;2(8135):170–173. doi: 10.1016/s0140-6736(79)91435-1. [DOI] [PubMed] [Google Scholar]
  3. Hoover R., Gray L. A., Sr, Fraumeni J. F., Jr Stilboestrol (diethylstilbestrol) and the risk of ovarian cancer. Lancet. 1977 Sep 10;2(8037):533–534. doi: 10.1016/s0140-6736(77)90667-5. [DOI] [PubMed] [Google Scholar]
  4. Iglesias R. Newer concepts in pathogenesis. Secondary endocrine and mammary malignancies as main signs of hormonal syndromes produced by endocrine tumors. Ann N Y Acad Sci. 1974;230:500–507. doi: 10.1111/j.1749-6632.1974.tb14485.x. [DOI] [PubMed] [Google Scholar]
  5. JABARA A. G. Induction of canine ovarian tumours by diethylstilboestrol and progesterone. Aust J Exp Biol Med Sci. 1962 Apr;40:139–152. doi: 10.1038/icb.1962.17. [DOI] [PubMed] [Google Scholar]
  6. Lemon H. M., Wotiz H. H., Parsons L., Mozden P. J. Reduced estriol excretion in patients with breast cancer prior to endocrine therapy. JAMA. 1966 Jun 27;196(13):1128–1136. [PubMed] [Google Scholar]
  7. Lynch H. T., Harris R. E., Guirgis H. A., Maloney K., Carmody L. L., Lynch J. F. Familial association of breast/ovarian carcinoma. Cancer. 1978 Apr;41(4):1543–1549. doi: 10.1002/1097-0142(197804)41:4<1543::aid-cncr2820410444>3.0.co;2-y. [DOI] [PubMed] [Google Scholar]
  8. MacMahon B., Cole P., Brown J. B., Aoki K., Lin T. M., Morgan R. W., Woo N. C. Urine oestrogen profiles of Asian and North American women. Int J Cancer. 1974 Aug 15;14(2):161–167. doi: 10.1002/ijc.2910140204. [DOI] [PubMed] [Google Scholar]
  9. MacMahon B., Cole P. The ovarian etiology of human breast cancer. Recent Results Cancer Res. 1972;39:185–192. [PubMed] [Google Scholar]
  10. Mattison D. R., Thorgeirsson S. S. Smoking and industrial pollution, and their effects on menopause and ovarian cancer. Lancet. 1978 Jan 28;1(8057):187–188. doi: 10.1016/s0140-6736(78)90617-7. [DOI] [PubMed] [Google Scholar]
  11. McKusick V. A., Weilbaecher R. G., Gragg G. W. Recessive inheritance of a congenital malformation syndrome: unilateral absence deformity of leg and congenital cataracts. JAMA. 1968 Apr 8;204(2):113–118. [PubMed] [Google Scholar]
  12. Newell G. R., Rawlings W., Krementz E. T., Roberts J. D. Multiple primary neoplasms in blacks compared to whites. 3. Initial cancers of the female breast and uterus. J Natl Cancer Inst. 1974 Aug;53(2):369–373. doi: 10.1093/jnci/53.2.369. [DOI] [PubMed] [Google Scholar]
  13. Nomura T. Carcinogenesis by urethan via mother's milk and its enhancement of transplacental carcinogenesis in mice. Cancer Res. 1973 Jul;33(7):1677–1683. [PubMed] [Google Scholar]
  14. Prior P., Waterhouse J. A. Incidence of bilateral tumours in a population-based series of breast-cancer patients. I. Two approaches to an epidemiological analysis. Br J Cancer. 1978 Apr;37(4):620–634. doi: 10.1038/bjc.1978.92. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Prior P., Waterhouse J. A. Multiple primary cancers of breast and cervix uteri: an epidemiological approach to analysis. Br J Cancer. 1981 May;43(5):623–631. doi: 10.1038/bjc.1981.92. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Prior P., Waterhouse J. A. Second primary cancers in patients with tumours of the salivary glands. Br J Cancer. 1977 Sep;36(3):362–368. doi: 10.1038/bjc.1977.201. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Prior P., Waterhouse J. A. The incidence of bilateral breast cancer: II. A proposed model for the analysis of coincidental tumours. Br J Cancer. 1981 May;43(5):615–622. doi: 10.1038/bjc.1981.91. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Reimer R. R., Hoover R., Fraumeni J. F., Jr, Young R. C. Second primary neoplasms following ovarian cancer. J Natl Cancer Inst. 1978 Nov;61(5):1195–1197. doi: 10.1093/jnci/61.5.1195. [DOI] [PubMed] [Google Scholar]
  19. Schoenberg B. S., Greenberg R. A., Eisenberg H. Occurrence of certain multiple primary cancers in females. J Natl Cancer Inst. 1969 Jul;43(1):15–32. doi: 10.1093/jnci/43.1.15. [DOI] [PubMed] [Google Scholar]
  20. Schottenfeld D., Berg J. Incidence of miltiple primary cancers. IV. Cancers of the female breast and genital organs. J Natl Cancer Inst. 1971 Jan;46(1):161–170. [PubMed] [Google Scholar]
  21. Sherman B. M., Korenman S. G. Inadequate corpus luteum function: a pathophysiological interpretation of human breast cancer epidemiology. Cancer. 1974 May;33(5):1306–1312. doi: 10.1002/1097-0142(197405)33:5<1306::aid-cncr2820330515>3.0.co;2-#. [DOI] [PubMed] [Google Scholar]
  22. Wang D. Y., Swain M. C., Hayward J. L., Bulbrook R. D. Hormones in the aetiology and clinical course of breast cancer. Recent Results Cancer Res. 1972;39:177–183. [PubMed] [Google Scholar]
  23. Ward H. W. Progestogen therapy for ovarian carcinoma. J Obstet Gynaecol Br Commonw. 1972 Jun;79(6):555–559. doi: 10.1111/j.1471-0528.1972.tb14200.x. [DOI] [PubMed] [Google Scholar]

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