Skip to main content
PMC home page
British Journal of Cancer logoLink to British Journal of Cancer
. 1982 May;45(5):655–669. doi: 10.1038/bjc.1982.106

The cancer research campaign (King's/Cambridge trial for early breast cancer: clinico-pathological aspects.

C W Elston, G A Gresham, G S Rao, T Zebro, J L Haybittle, J Houghton, G Kearney
PMCID: PMC2011009  PMID: 7044401

Abstract

Analysis of pathological data in the 10th year of follow-up of a multicentre trial of the management of operable breast cancer has confirmed the correlation of prognosis with tumour grade, tumour size and lymph-node status. For each factor examined there was no difference in survival between the 2 treatment groups ("watch policy" and radiotherapy) but patients in the WP group whose tumours were of Grade II or III or greater than 2 cm, or with lymph-node metastases, had a greater chance of local recurrence. Cellular reaction had no relationship with prognosis, except in patients with Grade III tumours. The clinical relevance and application of these results are discussed.

Full text

PDF
655

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BERG J. W. Inflammation and prognosis in breast cancer; a search for host resistance. Cancer. 1959 Jul-Aug;12(4):714–720. doi: 10.1002/1097-0142(195907/08)12:4<714::aid-cncr2820120414>3.0.co;2-b. [DOI] [PubMed] [Google Scholar]
  2. BLACK M. M., OPLER S. R., SPEER F. D. Survival in breast cancer cases in relation to the structure of the primary tumor and regional lymph nodes. Surg Gynecol Obstet. 1955 May;100(5):543–551. [PubMed] [Google Scholar]
  3. BLOOM H. J. G. Further studies on prognosis of breast carcinoma. Br J Cancer. 1950 Dec;4(4):347–367. doi: 10.1038/bjc.1950.34. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. BLOOM H. J. G. Prognosis in carcinoma of the breast. Br J Cancer. 1950 Sep;4(3):259–288. doi: 10.1038/bjc.1950.26. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. BLOOM H. J., RICHARDSON W. W. Histological grading and prognosis in breast cancer; a study of 1409 cases of which 359 have been followed for 15 years. Br J Cancer. 1957 Sep;11(3):359–377. doi: 10.1038/bjc.1957.43. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Baum M., Edwards M. H., Magarey C. J. Organization of clinical trial on national scale: management of early cancer of the breast. Br Med J. 1972 Nov 25;4(5838):476–478. doi: 10.1136/bmj.4.5838.476. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Blamey R. W., Davies C. J., Elston C. W., Johnson J., Haybittle J. L., Maynard P. V. Prognostic factors in breast cancer -- the formation of a prognostic index. Clin Oncol. 1979 Sep;5(3):227–236. [PubMed] [Google Scholar]
  8. Bloom H. J., Field J. R. Impact of tumor grade and host resistance on survival of women with breast cancer. Cancer. 1971 Dec;28(6):1580–1589. doi: 10.1002/1097-0142(197112)28:6<1580::aid-cncr2820280637>3.0.co;2-t. [DOI] [PubMed] [Google Scholar]
  9. Bloom H. J., Richardson W. W., Field J. R. Host resistance and survival in carcinoma of breast: a study of 104 cases of medullary carcinoma in a series of 1,411 cases of breast cancer followed for 20 years. Br Med J. 1970 Jul 25;3(5716):181–188. doi: 10.1136/bmj.3.5716.181. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Champion H. R., Wallace I. W., Prescott R. J. Histology in breast cancer prognosis. Br J Cancer. 1972 Apr;26(2):129–138. doi: 10.1038/bjc.1972.19. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Cutler S. J., Black M. M., Mork T., Harvei S., Freeman C. Further observations on prognostic factors in cancer of the female breast. Cancer. 1969 Oct;24(4):653–667. doi: 10.1002/1097-0142(196910)24:4<653::aid-cncr2820240402>3.0.co;2-b. [DOI] [PubMed] [Google Scholar]
  12. Eichner W. J., Lemon H. M., Friedell G. Tumor grade in the prognosis of breast cancer. Nebr State Med J. 1970 Jul;55(7):405–409. [PubMed] [Google Scholar]
  13. Fisher B., Slack N. H., Bross I. D. Cancer of the breast: size of neoplasm and prognosis. Cancer. 1969 Nov;24(5):1071–1080. doi: 10.1002/1097-0142(196911)24:5<1071::aid-cncr2820240533>3.0.co;2-h. [DOI] [PubMed] [Google Scholar]
  14. Fisher B., Slack N., Katrych D., Wolmark N. Ten year follow-up results of patients with carcinoma of the breast in a co-operative clinical trial evaluating surgical adjuvant chemotherapy. Surg Gynecol Obstet. 1975 Apr;140(4):528–534. [PubMed] [Google Scholar]
  15. Hamlin I. M. Possible host resistance in carcinoma of the breast: a histological study. Br J Cancer. 1968 Sep;22(3):383–401. doi: 10.1038/bjc.1968.47. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Ridolfi R. L., Rosen P. P., Port A., Kinne D., Miké V. Medullary carcinoma of the breast: a clinicopathologic study with 10 year follow-up. Cancer. 1977 Oct;40(4):1365–1385. doi: 10.1002/1097-0142(197710)40:4<1365::aid-cncr2820400402>3.0.co;2-n. [DOI] [PubMed] [Google Scholar]
  17. Wolff B. Histological grading in carcinoma of the breast. Br J Cancer. 1966 Mar;20(1):36–40. doi: 10.1038/bjc.1966.5. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from British Journal of Cancer are provided here courtesy of Cancer Research UK

RESOURCES