Abstract
Thirty hamsters about 10 weeks old were inoculated intraperitoneally with Leishmania donovani amastigotes and were serially killed after 15, 30, 45, 60, 75 and 85-90 days. Both the small and large intestines were examined grossly, and the histopathology was assessed by light and electron microscopy. The lamina propria and the submucosa of the whole length of the intestinal tract showed a progressive deposition of amyloid, selectively identified by optical and ultrastructural techniques. The presence of amyloid fibrils in the cytoplasm of plasma cells suggests that appearance of intestinal amyloidosis during visceral leishmaniasis may be the result of a pathological dysfunction of these cells. In addition to these deposits, the presence of inflammatory infiltrates containing lymphocytes, plasmocytes and macrophages confirmed the establishment of leishmaniasis. In the end-stages of the infection both vacuolar degeneration of the epithelial cells lining the lumen of the intestine and a moderate hyperplasia of lymphatic nodules was observed.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Anderson D. C., Buckner R. G., Glenn B. L., MacVean D. W. Endemic canine leishmaniasis. Vet Pathol. 1980 Jan;17(1):94–96. doi: 10.1177/030098588001700110. [DOI] [PubMed] [Google Scholar]
- Andrade Z. A., Andrade S. G. Alguns novos aspectos da patologia do calazar. (Estudo morfológico de 13 casos necropsiados) Rev Inst Med Trop Sao Paulo. 1966 Nov-Dec;8(6):259–266. [PubMed] [Google Scholar]
- Andrade Z. A., Iabuki K. A nefropatía do calazar. Rev Inst Med Trop Sao Paulo. 1972 Jan-Feb;14(1):51–54. [PubMed] [Google Scholar]
- Gonzalez J. L., Gallego E., Castaño M., Rueda A. Testicular amyloidosis in hamsters experimentally infected with Leishmania donovani. Br J Exp Pathol. 1983 Oct;64(5):518–523. [PMC free article] [PubMed] [Google Scholar]
- Lennox W. J., Smart M. E., Little P. B. Canine leishmaniasis in Canada. Can Vet J. 1972 Aug;13(8):188–190. [PMC free article] [PubMed] [Google Scholar]
- Veress B., Malik M. O., Satir A. A., el Hassan A. M. Morphological observations on visceral leishmaniasis in the Sudan. Trop Geogr Med. 1974 Jun;26(2):198–203. [PubMed] [Google Scholar]