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British Journal of Experimental Pathology logoLink to British Journal of Experimental Pathology
. 1988 Apr;69(2):301–308.

The effects of levamisole on urinary enzyme measurements and proximal tubule cell inclusions in male rats.

G O Evans 1, D A Goodwin 1, C E Parsons 1, N G Read 1
PMCID: PMC2013213  PMID: 2837266

Abstract

A markedly increased incidence of large angular secondary lysosomes was observed in the proximal tubular cells of male Wistar rats dosed orally with levamisole, 75 mg/kg body weight for 15 days. These inclusions were similar in appearance to those previously observed in male rats treated with decahydronaphthalene. Urinary enzymes were measured throughout the study, and of these enzymes lactate dehydrogenase and N-acetyl-beta-D-glucosaminidase activities were higher on days 9 and 13 for rats dosed with levamisole in comparison with control animals. Urine volumes increased for the levamisole treatment group, but no treatment related changes of urine protein output were found.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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