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. 1968 Apr;52(4):891–915.

Molecular pathology of in-vivo inhibition of protein synthesis. Electron microscopy of rat pancreatic acinar cells in puromycin-induced necrosis.

D S Longnecker, H Shinozuka, E Farber
PMCID: PMC2013375  PMID: 5643201

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. DARKEN M. A. PUROMYCIN INHIBITION OF PROTEIN SYNTHESIS. Pharmacol Rev. 1964 Sep;16:223–243. [PubMed] [Google Scholar]
  2. Estensen R. D., Baserga R. Puromycin-induced necrosis of crypt cells of the small intestine of mouse. J Cell Biol. 1966 Jul;30(1):13–22. doi: 10.1083/jcb.30.1.13. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. HERMAN L., FITZGERALD P. J. The degenerative changes in pancreatic acinar cells caused by DL-ethionine. J Cell Biol. 1962 Feb;12:277–296. doi: 10.1083/jcb.12.2.277. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. HRUBAN Z., SPARGO B., SWIFT H., WISSLER R. W., KLEINFELD R. G. Focal cytoplasmic degradation. Am J Pathol. 1963 Jun;42:657–683. [PMC free article] [PubMed] [Google Scholar]
  5. HRUBAN Z., SWIFT H., DUNN F. W., LEWIS D. E. EFFECT OF BETA-3-FURYLALANINE ON THE ULTRASTRUCTURE OF THE HEPATOCYTES AND PANCREATIC ACINAR CELLS. Lab Invest. 1965 Jan;14:70–80. [PubMed] [Google Scholar]
  6. HRUBAN Z., SWIFT H., WISSLER R. W. Effect of beta-3-thienylalanine on the formation of zymogen granules of exocrine pancreas. J Ultrastruct Res. 1962 Oct;7:359–372. doi: 10.1016/s0022-5320(62)90031-x. [DOI] [PubMed] [Google Scholar]
  7. HRUBAN Z., VILLA-TREVINO S., FARBER E. EFFECTS OF SOME PHENYLALANINE ANALOGS UPON PROTEIN METABOLISM IN VIVO. Lab Invest. 1965 May;14:468–474. [PubMed] [Google Scholar]
  8. Longnecker D. S., Farber E. Acute pancreatic necrosis induced by puromycin. Lab Invest. 1967 Mar;16(3):321–329. [PubMed] [Google Scholar]
  9. PALADE G. E. Intracisternal granules in the exocrine cells of the pancreas. J Biophys Biochem Cytol. 1956 Jul 25;2(4):417–422. doi: 10.1083/jcb.2.4.417. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Redman C. M., Sabatini D. D. Vectorial discharge of peptides released by puromycin from attached ribosomes. Proc Natl Acad Sci U S A. 1966 Aug;56(2):608–615. doi: 10.1073/pnas.56.2.608. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Rodriguez T. G. Ultrastructural changes in the mouse exocrine pancreas induced by prolonged treatment with actinomycin D. J Ultrastruct Res. 1967 Jul;19(1):116–129. doi: 10.1016/s0022-5320(67)80062-5. [DOI] [PubMed] [Google Scholar]
  12. SIEKEVITZ P., PALADE G. E. A cytochemical study on the pancreas of the guinea pig. II. Functional variations in the enzymatic activity of microsomes. J Biophys Biochem Cytol. 1958 May 25;4(3):309–318. doi: 10.1083/jcb.4.3.309. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Scott E. B. Histopathology of amino acid deficiencies. Arch Pathol. 1966 Aug;82(2):119–128. [PubMed] [Google Scholar]
  14. TRUMP B. F., SMUCKLER E. A., BENDITT E. P. A method for staining epoxy sections for light microscopy. J Ultrastruct Res. 1961 Aug;5:343–348. doi: 10.1016/s0022-5320(61)80011-7. [DOI] [PubMed] [Google Scholar]
  15. WEISBLUM B., HERMAN L., FITZGERALD P. J. Changes in pancreatic acinar cells during protein deprivation. J Cell Biol. 1962 Feb;12:313–327. doi: 10.1083/jcb.12.2.313. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. ZELANDER T., EKHOLM R., EDLUND Y. The ultrastructural organization of the rat exocrine pancreas. III. Intralobular vessels and nerves. J Ultrastruct Res. 1962 Aug;7:84–101. doi: 10.1016/s0022-5320(62)80029-x. [DOI] [PubMed] [Google Scholar]

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