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The American Journal of Pathology logoLink to The American Journal of Pathology
. 1978 Oct;93(1):45–52.

Ultrastructure of nitrosoheptamethyleneimine-induced lung tumors in European hamsters.

H Reznik-Schüller
PMCID: PMC2018326  PMID: 211850

Abstract

The ultrastructure of lung tumors induced in European hamsters through chronic subcutaneous treatment with nitrosoheptamethyleneimine (NHMI) is described. The neoplasms demonstrated either adenomatous (adenomas and adenocarcinomas) or mixed (tumors with areas of adenoid and squamous differentiation) pattern. Adenomatous areas consisted of Clara cells and of cells with lamellated inclusion bodies in their cytoplasm. Cells in areas with squamous differentiation contained cytoplasmic filaments and filament bundles as well as dense-cored granules.

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Selected References

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  1. BENSCH K. G., GORDON G. B., MILLER L. R. ELECTRON MICROSCOPIC AND BIOCHEMICAL STUDIES ON THE BRONCHIAL CARCINOID TUMOR. Cancer. 1965 May;18:592–602. doi: 10.1002/1097-0142(196505)18:5<592::aid-cncr2820180508>3.0.co;2-6. [DOI] [PubMed] [Google Scholar]
  2. BUCKINGHAM S., AVERY M. E. Time of appearance of lung surfactant in the foetal mouse. Nature. 1962 Feb 17;193:688–689. doi: 10.1038/193688a0. [DOI] [PubMed] [Google Scholar]
  3. Bensch K. G., Corrin B., Pariente R., Spencer H. Oat-cell carcinoma of the lung. Its origin and relationship to bronchial carcinoid. Cancer. 1968 Dec;22(6):1163–1172. doi: 10.1002/1097-0142(196811)22:6<1163::aid-cncr2820220612>3.0.co;2-l. [DOI] [PubMed] [Google Scholar]
  4. Bensch K. G., Gordon G. B., Miller L. R. Studies on the bronchial counterpart of the Kultschitzky (argentaffin) cell and innervation of bronchial glands. J Ultrastruct Res. 1965 Jun;12(5):668–686. doi: 10.1016/s0022-5320(65)80055-7. [DOI] [PubMed] [Google Scholar]
  5. Coalson J. J., Mohr J. A., Pirtle J. K., Dee A. L., Rhoades E. R. Electron microscopy of neoplasms in the lung with special emphasis on the alveolar cell carcinoma. Am Rev Respir Dis. 1970 Feb;101(2):181–197. doi: 10.1164/arrd.1970.101.2.181. [DOI] [PubMed] [Google Scholar]
  6. Cutz E., Chan W., Wong V., Conen P. E. Ultrastructure and fluorescence histochemistry of endocrine (APUD-type) cells in tracheal mucosa of human and various animal species. Cell Tissue Res. 1975 May 20;158(4):425–437. doi: 10.1007/BF00220210. [DOI] [PubMed] [Google Scholar]
  7. Garcia H., Lijinsky W. Tumorigenicity of five cyclic nitrosamines in MRC rats. Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1972;77(4):257–261. doi: 10.1007/BF00283967. [DOI] [PubMed] [Google Scholar]
  8. Hage E. Histochemistry and fine structure of endocrine cells in foetal lungs of the rabbit, mouse and guinea-pig. Cell Tissue Res. 1974 Jun 24;149(4):513–524. doi: 10.1007/BF00223029. [DOI] [PubMed] [Google Scholar]
  9. Hattori S., Matsuda M., Tateishi R., Nishihara H., Horai T. Oat-cell carcinoma of the lung. Clinical and morphological studies in relation to its histogenesis. Cancer. 1972 Oct;30(4):1014–1024. doi: 10.1002/1097-0142(197210)30:4<1014::aid-cncr2820300424>3.0.co;2-e. [DOI] [PubMed] [Google Scholar]
  10. KLAUS M., REISS O. K., TO OLEY W. H., PIEL C., CLEMENTS J. A. Alveolar epithelial cell mitochondria as source of the surface-active lung lining. Science. 1962 Sep 7;137(3532):750–751. doi: 10.1126/science.137.3532.750. [DOI] [PubMed] [Google Scholar]
  11. Lijinsky W., Tomatis L., Wenyon C. E. Lung tumors in rats treated with N-nitrosoheptamethyleneimine and N-nitrosooctamethyleneimine. Proc Soc Exp Biol Med. 1969 Mar;130(3):945–949. doi: 10.3181/00379727-130-33694. [DOI] [PubMed] [Google Scholar]
  12. Pattle R. E., Gandy G., Schock C., Creasey J. M. Lung inclusion bodies: different ultrastructure in simian and non-simian mammals. Experientia. 1974 Jul 15;30(7):797–798. doi: 10.1007/BF01924192. [DOI] [PubMed] [Google Scholar]
  13. Reznik-Schüller H., Mohr U. The ultrastructure of N-dibutylnitrosamine induced pulmonary tumours (adenocarcinomata) in European hamsters. Br J Cancer. 1975 Aug;32(2):230–238. doi: 10.1038/bjc.1975.153. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Reznik-Schüller H. Proliferation of endocrine (APUD-type) cells during early N-diethylnitrosamine-induced lung carcinogenesis in hamsters. Cancer Lett. 1976 May;1(5):255–258. doi: 10.1016/s0304-3835(75)97439-x. [DOI] [PubMed] [Google Scholar]
  15. Reznik-Schüller H. Sequential morphologic alterations in the bronchial epithelium of Syrian golden hamsters during N-nitrosomorpholine-induced pulmonary tumorigenesis. Am J Pathol. 1977 Oct;89(1):59–66. [PMC free article] [PubMed] [Google Scholar]
  16. Reznik-Schüller H. Ultrastructural alterations of APUD cells during nitrosamine-induced lung carcinogenesis. J Pathol. 1977 Feb;121(2):79–82. doi: 10.1002/path.1711210203. [DOI] [PubMed] [Google Scholar]
  17. Reznik-Schüller H. Ultrastructural alterations of nonciliated cells after nitrosamine treatment and their significance for pulmonary carcinogenesis. Am J Pathol. 1976 Dec;85(3):549–554. [PMC free article] [PubMed] [Google Scholar]
  18. Reznik G., Mohr U., Lijinsky W. Carcinogenicity of subcutaneously injected N-nitrosoheptamethyleneimine in European hamsters. J Natl Cancer Inst. 1978 Jul;61(1):239–243. doi: 10.1093/jnci/61.1.239. [DOI] [PubMed] [Google Scholar]
  19. Taylor H. W., Lijinsky W. Tumor induction in rats by feeding heptamethyleneimine and nitrite in water. Cancer Res. 1975 Mar;35(3):812–815. [PubMed] [Google Scholar]

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