Abstract
Alternariol and alternariol methyl ether were tested in the Ames Salmonella typhimurium assay, and both were shown, with and without metabolic activation, to be nonmutagenic to strains TA98 and TA100. The finding of other investigators that alternariol methyl ether is weakly mutagenic to TA98 without metabolic activation could have resulted from the presence of a small amount of one of the highly mutagenic altertoxins in the alternariol methyl ether originally tested.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Ames B. N., Mccann J., Yamasaki E. Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test. Mutat Res. 1975 Dec;31(6):347–364. doi: 10.1016/0165-1161(75)90046-1. [DOI] [PubMed] [Google Scholar]
- Davis V. M., Stack M. E. Mutagenicity of stemphyltoxin III, a metabolite of Alternaria alternata. Appl Environ Microbiol. 1991 Jan;57(1):180–182. doi: 10.1128/aem.57.1.180-182.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Scott P. M., Stoltz D. R. Mutagens produced by Alternaria alternata. Mutat Res. 1980 May;78(1):33–40. doi: 10.1016/0165-1218(80)90023-3. [DOI] [PubMed] [Google Scholar]
- Stack M. E., Mazzola E. P. Stemphyltoxin III from Alternaria alternata. J Nat Prod. 1989 Mar-Apr;52(2):426–427. doi: 10.1021/np50062a042. [DOI] [PubMed] [Google Scholar]
- Stack M. E., Prival M. J. Mutagenicity of the Alternaria metabolites altertoxins I, II, and III. Appl Environ Microbiol. 1986 Oct;52(4):718–722. doi: 10.1128/aem.52.4.718-722.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]