Abstract
The lognormal parametric statistical model can provide, for groups of carcinoma cervix patients, good estimates of long-term survival fractions several years earlier than would otherwise be possible. The present paper extends this model work to head and neck cancer by using a minimum chi-squared test for goodness of fit (P greater than 0-05), to study the distribution of survival times of patients who died with their cancer present. Some 12,000 case histories were available from 7 hospital registries, 4 regional cancer registries and one national registry (the OPCS). All histories were followed up for at least 10 years subsequent to treatment and could be grouped into one of 8 cancer sites: antrum, floor of mouth, larynx, nasopharynx, pyriform fossa, post cricoid, tonsil and tongue. The theoretical distributions investigated were the lognormal, negative exponential and skew exponential. The results showed that the lognormal provided the best overall fit to the data, although the range of optimum values for the lognormal parameter, S, differed with cancer site. The optimum range did, however, usually include the value S=0-45. These results will now permit the second stage of validation of the lognormal model to proceed for head and neck cancers.
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Selected References
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- Berg J. W. The distribution of cancer deaths in time. A survey test of the lognormal model. Br J Cancer. 1965 Dec;19(4):695–711. doi: 10.1038/bjc.1965.83. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HAYBITTLE J. L. The estimation of the proportion of patients cured after treatment for cancer of the breast. Br J Radiol. 1959 Nov;32:725–733. doi: 10.1259/0007-1285-32-383-725. [DOI] [PubMed] [Google Scholar]
- Mould R. F., Boag J. W. A test of several parametic statistical models for estimating success rate in the treatment of carcinoma cervix uteri. Br J Cancer. 1975 Nov;32(5):529–550. doi: 10.1038/bjc.1975.259. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Mould R. F. Calculation of survival rates by the life table and other methods. Clin Radiol. 1976 Jan;27(1):33–38. doi: 10.1016/s0009-9260(76)80011-6. [DOI] [PubMed] [Google Scholar]
- Mould R. F. Radiation treatment of cancer of the cervix of the uterus at the Radium Institute in Copenhagen from 1951-54. Acta Obstet Gynecol Scand. 1975;54(4):389–391. doi: 10.3109/00016347509156774. [DOI] [PubMed] [Google Scholar]
- Ronnike F. Carcinoma of the vulva. Cure after operative therapy evaluated in accordance with Boag's statistical method. Dan Med Bull. 1968 Dec;15(10):296–301. [PubMed] [Google Scholar]
- TIVEY H. The prognosis for survival in chronic granulocytic and lymphocytic leukemia. Am J Roentgenol Radium Ther Nucl Med. 1954 Jul;72(1):68–93. [PubMed] [Google Scholar]