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. 1977 Aug;36(2):221–226. doi: 10.1038/bjc.1977.181

Metastasis of a transplantable mammary tumour in rats treated with cyclophosphamide and/or irradiation.

J V Moore, B Dixon
PMCID: PMC2025474  PMID: 911660

Abstract

We report observations on the spread by metastasis and infiltration of a transplantable tumour in rats treated by 60Co gamma-irradiation of the primary, irradiation plus parenteral cyclophosphamide, or parenteral cyclophosphamide alone. The proportion of animals with overt disseminated disease and the extent of spread were measured with respect to the time elapsed after implantation and treatment of the primary tumour. The incidence of metastatic disease was broadly similar for all treatment groups, but the extent of dissemination was greater in rats whose treatment included cyclophosphamide.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Brunner K. W., Marthaler T., Müller W. Unfavourable effects of long-term adjuvant chemotherapy with Endoxan in radically operated bronchogenic carcinoma. Eur J Cancer. 1971 Aug;7(4):285–294. doi: 10.1016/0014-2964(71)90071-5. [DOI] [PubMed] [Google Scholar]
  2. Choi C. H., Carey R. W. Small cell anaplastic carcinoma of lung. Reappraisal of current management. Cancer. 1976 Jun;37(6):2651–2657. doi: 10.1002/1097-0142(197606)37:6<2651::aid-cncr2820370612>3.0.co;2-g. [DOI] [PubMed] [Google Scholar]
  3. Fisher B., Fisher E. R., Feduska N. Trauma and the localization of tumor cells. Cancer. 1967 Jan;20(1):23–30. doi: 10.1002/1097-0142(1967)20:1<23::aid-cncr2820200103>3.0.co;2-p. [DOI] [PubMed] [Google Scholar]
  4. Harris J., Sengar D., Stewart T., Hyslop D. The effect of immunosuppressive chemotherapy on immune function in patients with malignant disease. Cancer. 1976 Feb;37(2 Suppl):1058–1069. doi: 10.1002/1097-0142(197602)37:2+<1058::aid-cncr2820370813>3.0.co;2-o. [DOI] [PubMed] [Google Scholar]
  5. Roswit B., Liberson S., Ohanian M., Kusik H., Petrovich Z. Survival with inoperable lung cancer. Controlled national Veterans Administration study of radiation and chemotherapy. N Y State J Med. 1976 Apr;76(4):560–564. [PubMed] [Google Scholar]
  6. Sheldon P. W., Fowler J. F. The effect of irradiating a transplanted murine lymphosarcoma on the subsequent development of metastases. Br J Cancer. 1973 Dec;28(6):508–514. doi: 10.1038/bjc.1973.180. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Slavin R. E., Millan J. C., Mullins G. M. Pathology of high dose intermittent cyclophosphamide therapy. Hum Pathol. 1975 Nov;6(6):693–709. doi: 10.1016/s0046-8177(75)80078-5. [DOI] [PubMed] [Google Scholar]
  8. Steel G. G., Adams K. Stem-cell survival and tumor control in the Lewis lung carcinoma. Cancer Res. 1975 Jun;35(6):1530–1535. [PubMed] [Google Scholar]
  9. Sugarbaker E. V., Cohen A. M., Ketcham A. S. Facilitated metastatic distribution of the Walker 256 tumor in Sprague-Dawley rats with hydrocortisone and-or cyclophosphamide. J Surg Oncol. 1970;2(3):277–289. doi: 10.1002/jso.2930020312. [DOI] [PubMed] [Google Scholar]
  10. THOMLINSON R. H. An experimental method for comparing treatments of intact malignant tumours in animals and its application to the use of oxygen in radiotherapy. Br J Cancer. 1960 Sep;14:555–576. doi: 10.1038/bjc.1960.62. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Thomlinson R. H., Craddock E. A. The gross response of an experimental tumour to single doses of x-rays. Br J Cancer. 1967 Mar;21(1):108–123. doi: 10.1038/bjc.1967.10. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Tucker R. D., Sealy R., van Wyk C., le Roux P. L., Soskolne C. L. A clinical trial of cyclophosphamide (NSC-26271) and radiation therapy for oat cell carcinoma of the lung. Cancer Chemother Rep 3. 1973 Mar;4(2):159–160. [PubMed] [Google Scholar]
  13. Twentyman P. R., Bleehen N. M. The sensitivity to cytotoxic agents of the EMT6 tumor in vivo. Comparative response of lung nodules in rapid expotential growth and of the solid flank tumour. Br J Cancer. 1976 Mar;33(3):320–328. doi: 10.1038/bjc.1976.46. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Van den Brenk H. A., Sharpington C. Effect of local x-irradiation of a primary sarcoma in the rat on dissemination and growth of metastases: dose-response characteristics. Br J Cancer. 1971 Dec;25(4):812–830. doi: 10.1038/bjc.1971.95. [DOI] [PMC free article] [PubMed] [Google Scholar]

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