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. 1977 Mar;86(3):685–692.

Patterns of cellular proliferation in normal and tumor cell populations.

S M Gartler
PMCID: PMC2032114  PMID: 402817

Abstract

Three types of cell mosaics have been used in mammalian studies: hemopoietic shimeras, mosaics formed by aggregation of preimplatation embryos, and mosaics resulting from X-chromosome inactivation. The problems investigated with these cell mosaics have included normal tissue orgaization, cell selection, primordial cell pool sizes, and tumor cell kinetics. The emphasis in this review is on the application of X-chromosome inactivation mosaics to the analysis of tumor cell proliferation. The first application of mosaicism to tumor ontogeny involved leiomyomas and demonstrated single cell and independent origin of the tumors. Other tumor studies are reviewed including those of presumed multiple cell origin, especially those of hereditary origin and viral etiology. The concept of target size is invoked to explain these multiple cell origin tumors. The recent reports on the clonal nature of atherosclerotic plaques is also discussed. Emphasis is placed on resolving the relationship between the multiclonal underlying fatty streak and the clonal plaque in order to understand the implications of the clonal plaques.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Benditt E. P., Benditt J. M. Evidence for a monoclonal origin of human atherosclerotic plaques. Proc Natl Acad Sci U S A. 1973 Jun;70(6):1753–1756. doi: 10.1073/pnas.70.6.1753. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Benditt E. P. Evidence for a monoclonal origin of human atherosclerotic plaques and some implications. Circulation. 1974 Oct;50(4):650–652. doi: 10.1161/01.cir.50.4.650. [DOI] [PubMed] [Google Scholar]
  3. Chu E. W., Rabson A. S. Chimerism in lymphoid cell culture line derived from lymph node of marmoset infected with Herpesvirus saimiri. J Natl Cancer Inst. 1972 Mar;48(3):771–775. [PubMed] [Google Scholar]
  4. Fialkow P. J., Klein E., Klein G., Clifford P., Singh S. Immunoglobulin and glucose-6-phosphate dehydrogenase as markers of cellular origin in Burkitt lymphoma. J Exp Med. 1973 Jul 1;138(1):89–102. doi: 10.1084/jem.138.1.89. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Fialkow P. J., Sagebiel R. W., Gartler S. M., Rimoin D. L. Multiple cell origin of hereditary neurofibromas. N Engl J Med. 1971 Feb 11;284(6):298–300. doi: 10.1056/NEJM197102112840604. [DOI] [PubMed] [Google Scholar]
  6. Fialkow P. J., Thomas E. D., Bryant J. I., Neiman P. E. Leukaemic transformation of engrafted human marrow cells in vivo. Lancet. 1971 Feb 6;1(7693):251–255. doi: 10.1016/s0140-6736(71)90998-6. [DOI] [PubMed] [Google Scholar]
  7. Friedman J. M., Fialkow P. J. Viral "tumorigenesis" in man: cell markers in condylomata acuminata. Int J Cancer. 1976 Jan 15;17(1):57–61. doi: 10.1002/ijc.2910170109. [DOI] [PubMed] [Google Scholar]
  8. GARTLER S. M., LINDER D. SELECTION IN MAMMALIAN MOSAIC CELL POPULATIONS. Cold Spring Harb Symp Quant Biol. 1964;29:253–260. doi: 10.1101/sqb.1964.029.01.028. [DOI] [PubMed] [Google Scholar]
  9. GARTLER S. M., WAXMAN S. H., GIBLETT E. An XX/XY human hermaphrodite resulting from double fertilization. Proc Natl Acad Sci U S A. 1962 Mar 15;48:332–335. doi: 10.1073/pnas.48.3.332. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Gandini E., Gartler S. M., Angioni G., Argiolas N., Dell'Acqua G. Developmental implications of multiple tissue studies in glucose-6-phosphate dehydrogenase-deficient heterozygotes. Proc Natl Acad Sci U S A. 1968 Nov;61(3):945–948. doi: 10.1073/pnas.61.3.945. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Gartler S. M., Gansini E., Hutchison H. T., Campbell B., Zechhi G. Glucose-6-phosphate dehydrogenase mosaicism: ito;ozatopm om tje study of hair follicle variegation. Ann Hum Genet. 1971 Jul;35(1):1–7. [PubMed] [Google Scholar]
  12. Gartler S. M., Ziprkowski L., Krakowski A., Ezra R., Szeinberg A., Adam A. Glucose-6-phosphate dehydrogenase mosaicism as a tracer in the study of hereditary multiple trichoepithelioma. Am J Hum Genet. 1966 May;18(3):282–287. [PMC free article] [PubMed] [Google Scholar]
  13. LINDER D., GARTLER S. M. DISTRIBUTION OF GLUCOSE-6-PHOSPHATE DEHYDROGENASE ELECTROPHORETIC VARIANTS IN DIFFERENT TISSUES OF HETEROZYGOTES. Am J Hum Genet. 1965 May;17:212–220. [PMC free article] [PubMed] [Google Scholar]
  14. Linder D., Gartler S. M. Glucose-6-phosphate dehydrogenase mosaicism: utilization as a cell marker in the study of leiomyomas. Science. 1965 Oct 1;150(3692):67–69. doi: 10.1126/science.150.3692.67. [DOI] [PubMed] [Google Scholar]
  15. Lyon M. F. Mechanisms and evolutionary origins of variable X-chromosome activity in mammals. Proc R Soc Lond B Biol Sci. 1974 Nov 5;187(1088):243–268. doi: 10.1098/rspb.1974.0073. [DOI] [PubMed] [Google Scholar]
  16. Martin G. M., Sprague C. A. Symposium on in vitro studies related to atherogenesis. Life histories of hyperplastoid cell lines from aorta and skin. Exp Mol Pathol. 1973 Apr;18(2):125–141. doi: 10.1016/0014-4800(73)90012-9. [DOI] [PubMed] [Google Scholar]
  17. Mintz B., Custer R. P., Donnelly A. J. Genetic diseases and developmental defects analyzed in allophenic mice. Int Rev Exp Pathol. 1971;10:143–179. [PubMed] [Google Scholar]
  18. Murray R. F., Hobbs J., Payne B. Possible clonal origin of common warts (Verruca vulgaris). Nature. 1971 Jul 2;232(5305):51–52. doi: 10.1038/232051a0. [DOI] [PubMed] [Google Scholar]
  19. Nyhan W. L., Bakay B., Connor J. D., Marks J. F., Keele D. K. Hemizygous expression of glucose-6-phosphate dehydrogenase in erythrocytes of heterozygotes for the Lesch-Nyhan syndrome. Proc Natl Acad Sci U S A. 1970 Jan;65(1):214–218. doi: 10.1073/pnas.65.1.214. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Pearson T. A., Wang B. A., Solez K., Heptinstall R. H. Clonal characteristics of fibrous plaques and fatty streaks from human aortas. Am J Pathol. 1975 Nov;81(2):379–387. [PMC free article] [PubMed] [Google Scholar]
  21. Ross R., Glomset J. A. Atherosclerosis and the arterial smooth muscle cell: Proliferation of smooth muscle is a key event in the genesis of the lesions of atherosclerosis. Science. 1973 Jun 29;180(4093):1332–1339. doi: 10.1126/science.180.4093.1332. [DOI] [PubMed] [Google Scholar]
  22. Rossi H. H., Kellerer A. M. Radiation carcinogenesis at low doses. Science. 1972 Jan 14;175(4018):200–202. doi: 10.1126/science.175.4018.200. [DOI] [PubMed] [Google Scholar]
  23. TARKOWSKI A. K. Mouse chimaeras developed from fused eggs. Nature. 1961 Jun 3;190:857–860. doi: 10.1038/190857a0. [DOI] [PubMed] [Google Scholar]
  24. Wu A. M., Till J. E., Siminovitch L., McCulloch E. A. Cytological evidence for a relationship between normal hemotopoietic colony-forming cells and cells of the lymphoid system. J Exp Med. 1968 Mar 1;127(3):455–464. doi: 10.1084/jem.127.3.455. [DOI] [PMC free article] [PubMed] [Google Scholar]

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