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. 1975 Nov;81(2):303–321.

Surface epithelium of the developing ovary. Possible correlation with ovarian neoplasia.

B Gondos
PMCID: PMC2032215  PMID: 1190291

Abstract

The surface epithelium of the fetal ovary undergoes diffuse proliferation during the fourth and fifth months of gestation, after which it reverts to a single layer separated from the developing cortex by a tunica albuginea. The proliferation is associated with marked nuclear irregularity and pleomorphism similar to that seen in surface epithelial neoplasms. The epithelial changes occur during the same time period that interstitial cells with ultrastructural and histochemical properties of steroid-secreting tissue appear in the ovarian stroma. The possible role of steroid hormones in stimulating surface epithelial proliferation is discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BLOCH E. METABOLISM OF 4-14C-PROGESTERONE BY HUMAN FETAL TESTIS AND OVARIES. Endocrinology. 1964 Jun;74:833–845. doi: 10.1210/endo-74-6-833. [DOI] [PubMed] [Google Scholar]
  2. Brandau H., Lehmann V. Histoenzymatische Untersuchungen an menschlichen Gonaden während der intrauterinen Entwicklung. Z Geburtshilfe Gynakol. 1970;173(3):233–249. [PubMed] [Google Scholar]
  3. Bransilver B. R., Ferenczy A., Richart R. M. Brenner tumors and Walthard cell nests. Arch Pathol. 1974 Aug;98(2):76–86. [PubMed] [Google Scholar]
  4. Cutler B. S., Forbes A. P., Ingersoll F. M., Scully R. E. Endometrial carcinoma after stilbestrol therapy in gonadal dysgenesis. N Engl J Med. 1972 Sep 28;287(13):628–631. doi: 10.1056/NEJM197209282871302. [DOI] [PubMed] [Google Scholar]
  5. Dehner L. P., Norris H. J., Garner F. M., Taylor H. B. Comparative pathology of ovarian neoplasms. 3. Germ cell tumours of canine, bovine, feline, rodent and human species. J Comp Pathol. 1970 Apr;80(2):299–306. doi: 10.1016/0021-9975(70)90098-8. [DOI] [PubMed] [Google Scholar]
  6. Forsberg J. G. Cervicovaginal epithelium: its origin and development. Am J Obstet Gynecol. 1973 Apr 1;115(7):1025–1043. doi: 10.1016/0002-9378(73)90687-x. [DOI] [PubMed] [Google Scholar]
  7. Forsberg J. G. Estrogen, vaginal cancer, and vaginal development. Am J Obstet Gynecol. 1972 May 1;113(1):83–87. doi: 10.1016/0002-9378(72)90456-5. [DOI] [PubMed] [Google Scholar]
  8. Goldman A. S., Yakovac W. C., Bongiovanni A. M. Development of activity of 3 beta-hydroxysteroid dehydrogenase in human fetal tissues and in two anencephalic newborns. J Clin Endocrinol Metab. 1966 Jan;26(1):14–22. doi: 10.1210/jcem-26-1-14. [DOI] [PubMed] [Google Scholar]
  9. Gondos B., Bhiraleus P., Hobel C. J. Ultrastructural observations on germ cells in human fetal ovaries. Am J Obstet Gynecol. 1971 Jul 1;110(5):644–652. doi: 10.1016/0002-9378(71)90245-6. [DOI] [PubMed] [Google Scholar]
  10. Gondos B. Electron microscopic study of papillary serous tumors of the ovary. Cancer. 1971 Jun;27(6):1455–1464. doi: 10.1002/1097-0142(197106)27:6<1455::aid-cncr2820270628>3.0.co;2-b. [DOI] [PubMed] [Google Scholar]
  11. Gondos B., Hobel C. J. Interstitial cells in the human fetal ovary. Endocrinology. 1973 Sep;93(3):736–739. doi: 10.1210/endo-93-3-736. [DOI] [PubMed] [Google Scholar]
  12. Gondos B. Ultrastructure of the germinal epithelium during oogenesis in the rabbit. J Exp Zool. 1969 Dec;172(4):465–479. doi: 10.1002/jez.1401720409. [DOI] [PubMed] [Google Scholar]
  13. Herbst A. L., Robboy S. J., Scully R. E., Poskanzer D. C. Clear-cell adenocarcinoma of the vagina and cervix in girls: analysis of 170 registry cases. Am J Obstet Gynecol. 1974 Jul 1;119(5):713–724. [PubMed] [Google Scholar]
  14. Jungmann R. A., Schweppe J. S. Biosynthesis of sterols and steroids from acetate-14-C by human fetal ovaries. J Clin Endocrinol Metab. 1968 Nov;28(11):1599–1604. doi: 10.1210/jcem-28-11-1599. [DOI] [PubMed] [Google Scholar]
  15. Kyriakos M., Kempson R. L., Konikov N. F. A clinical and pathologic study of endocervical lesions associated with oral contraceptives. Cancer. 1968 Jul;22(1):99–110. doi: 10.1002/1097-0142(196807)22:1<99::aid-cncr2820220113>3.0.co;2-4. [DOI] [PubMed] [Google Scholar]
  16. Langley F. A., Cummins P. A., Fox H. An ultrastructural study of mucin secreting epithelia in ovarian neoplasms. Acta Pathol Microbiol Scand Suppl. 1972;233:76–86. [PubMed] [Google Scholar]
  17. Linder D., McCaw B. K., Hecht F. Parthenogenic origin of benign ovarian teratomas. N Engl J Med. 1975 Jan 9;292(2):63–66. doi: 10.1056/NEJM197501092920202. [DOI] [PubMed] [Google Scholar]
  18. Motta P. Observations on the ultrastructure of the interstitial cells of the human ovary. Anat Anz. 1972;130(1):1–17. [PubMed] [Google Scholar]
  19. Papadaki L., Beilby J. O. The fine structure of the surface epithelium of the human ovary. J Cell Sci. 1971 Mar;8(2):445–465. doi: 10.1242/jcs.8.2.445. [DOI] [PubMed] [Google Scholar]
  20. Roberts D. K., Marshall R. B., Wharton J. T. Ultrastructure of ovarian tumors. I. Papillary serous cystadenocarcinoma. Cancer. 1970 Apr;25(4):947–958. doi: 10.1002/1097-0142(197004)25:4<947::aid-cncr2820250432>3.0.co;2-o. [DOI] [PubMed] [Google Scholar]
  21. SABATINI D. D., BENSCH K., BARRNETT R. J. Cytochemistry and electron microscopy. The preservation of cellular ultrastructure and enzymatic activity by aldehyde fixation. J Cell Biol. 1963 Apr;17:19–58. doi: 10.1083/jcb.17.1.19. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Scully R. E. Recent progress in ovarian cancer. Hum Pathol. 1970 Mar;1(1):73–98. doi: 10.1016/s0046-8177(70)80005-3. [DOI] [PubMed] [Google Scholar]
  23. Silverberg S. G. Ultrastructure and histogenesis of clear cell carcinoma of the ovary. Am J Obstet Gynecol. 1973 Feb 1;115(3):394–400. doi: 10.1016/0002-9378(73)90596-6. [DOI] [PubMed] [Google Scholar]
  24. VENABLE J. H., COGGESHALL R. A SIMPLIFIED LEAD CITRATE STAIN FOR USE IN ELECTRON MICROSCOPY. J Cell Biol. 1965 May;25:407–408. doi: 10.1083/jcb.25.2.407. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Vossmeyer J. Zur Cytologie der pränatalen Gonaden-Entwicklung beim Menschen. I. Die Histogenese des Hodens, an Eponschnitten untersucht. Z Anat Entwicklungsgesch. 1971;134(2):146–164. [PubMed] [Google Scholar]
  26. WATSON M. L. Staining of tissue sections for electron microscopy with heavy metals. J Biophys Biochem Cytol. 1958 Jul 25;4(4):475–478. doi: 10.1083/jcb.4.4.475. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Weakley B. S. Differentiation of the surface epithelium of the hamster ovary. An electron microscopic study. J Anat. 1969 Jul;105(Pt 1):129–147. [PMC free article] [PubMed] [Google Scholar]
  28. Wilkinson E. J., Friedrich E. G., Jr, Mattingly R. F., Regali J. A., Garancis J. C. Turner's syndrome with endometrial adenocarcinoma and stilbestrol therapy. Obstet Gynecol. 1973 Aug;42(2):193–200. [PubMed] [Google Scholar]

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