Skip to main content
PMC home page
The American Journal of Pathology logoLink to The American Journal of Pathology
. 1976 Dec;85(3):549–554.

Ultrastructural alterations of nonciliated cells after nitrosamine treatment and their significance for pulmonary carcinogenesis.

H Reznik-Schüller
PMCID: PMC2032650  PMID: 999758

Abstract

Syrian golden hamsters received multiple subcutaneous injections of N-diethylnitrosamine (DEN) or N-dibutylnitrosamine (DBN). Ultrastructural examination of the sequential alterations of bronchial epithelia was performed. Starting from the third to fourth treatment, the formation of lamellated inclusion bodies (LBs) was observed in nonciliated cells of segmental bronchi and peripheral bronchioles. These organelles closely resembled those LBs normally found in alveolar epithelial cells Type 2, which are a characteristic feature of alveolar cell carcinomas.

Full text

PDF
554

Images in this article

554Figure 3
on p.554
554Figure 4
on p.554
553Figure 1
on p.553
553Figure 2
on p.553

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Adamson J. S., Senior R. M., Merrill T. Alveolar cell carcinoma. An electron microscopic study. Am Rev Respir Dis. 1969 Oct;100(4):550–557. doi: 10.1164/arrd.1969.100.4.550. [DOI] [PubMed] [Google Scholar]
  2. Althoff J., Krüger F. W., Mohr U., Schmahl D. Dibutylnitrosamine carcinogenesis in Syrian Golden and Chinese hamsters. Proc Soc Exp Biol Med. 1971 Jan;136(1):168–173. doi: 10.3181/00379727-136-35219. [DOI] [PubMed] [Google Scholar]
  3. Althoff J., Mohr U., Page N., Reznik G. Carcinogenic effect of dibutylnitrosamine in European hamsters (Cricetus cricetus). J Natl Cancer Inst. 1974 Sep;53(3):795–800. doi: 10.1093/jnci/53.3.795. [DOI] [PubMed] [Google Scholar]
  4. Althoff J., Wilson R., Mohr U. Diethylnitrosamine-induced alterations in the tracheobronchial system of Syrian golden hamsters. J Natl Cancer Inst. 1971 May;46(5):1067–1071. [PubMed] [Google Scholar]
  5. BUCKINGHAM S., AVERY M. E. Time of appearance of lung surfactant in the foetal mouse. Nature. 1962 Feb 17;193:688–689. doi: 10.1038/193688a0. [DOI] [PubMed] [Google Scholar]
  6. CAMPICHE M. A., GAUTIER A., HERNANDEZ E. I., REYMOND A. AN ELECTRON MICROSCOPE STUDY OF THE FETAL DEVELOPMENT OF HUMAN LUNG. Pediatrics. 1963 Dec;32:976–994. [PubMed] [Google Scholar]
  7. Coalson J. J., Mohr J. A., Pirtle J. K., Dee A. L., Rhoades E. R. Electron microscopy of neoplasms in the lung with special emphasis on the alveolar cell carcinoma. Am Rev Respir Dis. 1970 Feb;101(2):181–197. doi: 10.1164/arrd.1970.101.2.181. [DOI] [PubMed] [Google Scholar]
  8. Creasey J. M., Pattle R. E., Schock C. Ultrastructure of inclusion bodies in type II cells of lung, human and sub-simian. J Physiol. 1974 Mar;237(2):35P–37P. [PubMed] [Google Scholar]
  9. DONTENWILL W., MOHR U. [Carcinoma of the respiratory tract following treatment of the golden hamster with diethylnitrosamine]. Z Krebsforsch. 1961;64:305–312. [PubMed] [Google Scholar]
  10. HERROLD K. M., DUNHAM L. J. Induction of tumors in the Syrian hamster with diethylnitrosamine (N-nitrosodiethylamine). Cancer Res. 1963 Jun;23:773–777. [PubMed] [Google Scholar]
  11. Hage E. The morphological development of the pulmonary epithelium of human foetuses studied by light- and electron microscopy. Z Anat Entwicklungsgesch. 1973 Aug 30;140(3):271–279. doi: 10.1007/BF00525057. [DOI] [PubMed] [Google Scholar]
  12. KLAUS M., REISS O. K., TO OLEY W. H., PIEL C., CLEMENTS J. A. Alveolar epithelial cell mitochondria as source of the surface-active lung lining. Science. 1962 Sep 7;137(3532):750–751. doi: 10.1126/science.137.3532.750. [DOI] [PubMed] [Google Scholar]
  13. O'Hare K. H., Sheridan M. N. Electron microscopic observations on the morphogenesis of the albino rat lung, with special reference to pulmonary epithelial cells. Am J Anat. 1970 Feb;127(2):181–205. doi: 10.1002/aja.1001270205. [DOI] [PubMed] [Google Scholar]
  14. Pattle R. E., Gandy G., Schock C., Creasey J. M. Lung inclusion bodies: different ultrastructure in simian and non-simian mammals. Experientia. 1974 Jul 15;30(7):797–798. doi: 10.1007/BF01924192. [DOI] [PubMed] [Google Scholar]
  15. Reznik-Schüller H., Mohr U. The ultrastructure of N-dibutylnitrosamine induced pulmonary tumours (adenocarcinomata) in European hamsters. Br J Cancer. 1975 Aug;32(2):230–238. doi: 10.1038/bjc.1975.153. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Spit B. J., Feron V. J. Comparative study of the ultrastructure of Tracheal and pulmonary tumours induced by multiple intratracheal instillations of diethylnitrosamine in Syrian golden hamsters. Eur J Cancer. 1975 Dec;11(12):867–872. doi: 10.1016/0014-2964(75)90086-9. [DOI] [PubMed] [Google Scholar]
  17. Straks W., Feron V. J. Ultrastructure of pulmonary adenomas induced by intratracheal instillation of diethylnitrosamine in Syrian golden hamsters. Eur J Cancer. 1973 May;9(5):359–362. doi: 10.1016/0014-2964(73)90051-0. [DOI] [PubMed] [Google Scholar]

Articles from The American Journal of Pathology are provided here courtesy of American Society for Investigative Pathology

RESOURCES