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. 1995 Mar;71(3):614–616. doi: 10.1038/bjc.1995.119

Level of expression of E-cadherin mRNA in colorectal cancer correlates with clinical outcome.

S Dorudi 1, A M Hanby 1, R Poulsom 1, J Northover 1, I R Hart 1
PMCID: PMC2033614  PMID: 7880746

Abstract

A series of colorectal carcinomas (n = 49) resected from patients with known clinical outcomes were analysed for E-cadherin expression using in situ hybridisation to measure mRNA. Patients surviving 5 years or longer (n = 31) exhibited significantly higher levels of E-cadherin mRNA than those surviving less than 5 years (n = 18, P = 0.003). These preliminary results from this small sample suggest that E-cadherin expression may be a useful prognostic marker in colorectal cancer patients.

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Selected References

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