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. 1995 Sep;72(3):800–803. doi: 10.1038/bjc.1995.415

Trends in mortality from primary liver cancer in England and Wales 1975-92: influence of oral contraceptives.

J W Mant 1, M P Vessey 1
PMCID: PMC2033882  PMID: 7669599

Abstract

Numerous case-control studies have suggested a link between the oral contraceptive pill and liver cancer. The secular trends in liver cancer mortality rates for England and Wales from 1975 to 1992 were examined to determine whether an effect of the pill was apparent. Liver cancer mortality has remained constant in women in the age groups that have had major exposure to the pill.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Colditz G. A. Oral contraceptive use and mortality during 12 years of follow-up: the Nurses' Health Study. Ann Intern Med. 1994 May 15;120(10):821–826. doi: 10.7326/0003-4819-120-10-199405150-00002. [DOI] [PubMed] [Google Scholar]
  2. Forman D., Doll R., Peto R. Trends in mortality from carcinoma of the liver and the use of oral contraceptives. Br J Cancer. 1983 Sep;48(3):349–354. doi: 10.1038/bjc.1983.199. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Forman D., Vincent T. J., Doll R. Cancer of the liver and the use of oral contraceptives. Br Med J (Clin Res Ed) 1986 May 24;292(6532):1357–1361. doi: 10.1136/bmj.292.6532.1357. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Henderson B. E., Preston-Martin S., Edmondson H. A., Peters R. L., Pike M. C. Hepatocellular carcinoma and oral contraceptives. Br J Cancer. 1983 Sep;48(3):437–440. doi: 10.1038/bjc.1983.210. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Hsing A. W., Hoover R. N., McLaughlin J. K., Co-Chien H. T., Wacholder S., Blot W. J., Fraumeni J. F., Jr Oral contraceptives and primary liver cancer among young women. Cancer Causes Control. 1992 Jan;3(1):43–48. doi: 10.1007/BF00051911. [DOI] [PubMed] [Google Scholar]
  6. Kew M. C., Song E., Mohammed A., Hodkinson J. Contraceptive steroids as a risk factor for hepatocellular carcinoma: a case/control study in South African black women. Hepatology. 1990 Feb;11(2):298–302. doi: 10.1002/hep.1840110221. [DOI] [PubMed] [Google Scholar]
  7. La Vecchia C., Negri E., Parazzini F. Oral contraceptives and primary liver cancer. Br J Cancer. 1989 Mar;59(3):460–461. doi: 10.1038/bjc.1989.94. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Mayans M. V., Calvet X., Bruix J., Bruguera M., Costa J., Estève J., Bosch F. X., Bru C., Rodés J. Risk factors for hepatocellular carcinoma in Catalonia, Spain. Int J Cancer. 1990 Sep 15;46(3):378–381. doi: 10.1002/ijc.2910460307. [DOI] [PubMed] [Google Scholar]
  9. Neuberger J., Forman D., Doll R., Williams R. Oral contraceptives and hepatocellular carcinoma. Br Med J (Clin Res Ed) 1986 May 24;292(6532):1355–1357. doi: 10.1136/bmj.292.6532.1355. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Palmer J. R., Rosenberg L., Kaufman D. W., Warshauer M. E., Stolley P., Shapiro S. Oral contraceptive use and liver cancer. Am J Epidemiol. 1989 Nov;130(5):878–882. doi: 10.1093/oxfordjournals.aje.a115420. [DOI] [PubMed] [Google Scholar]
  11. Prentice R. L. Epidemiologic data on exogenous hormones and hepatocellular carcinoma and selected other cancers. Prev Med. 1991 Jan;20(1):38–46. doi: 10.1016/0091-7435(91)90005-o. [DOI] [PubMed] [Google Scholar]
  12. Tavani A., Negri E., Parazzini F., Franceschi S., La Vecchia C. Female hormone utilisation and risk of hepatocellular carcinoma. Br J Cancer. 1993 Mar;67(3):635–637. doi: 10.1038/bjc.1993.116. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Trichopoulos D. Etiology of primary liver cancer and the role of steroidal hormones. Cancer Causes Control. 1992 Jan;3(1):3–5. doi: 10.1007/BF00051905. [DOI] [PubMed] [Google Scholar]
  14. Villard-Mackintosh L., Vessey M. P., Jones L. The effects of oral contraceptives and parity on ovarian cancer trends in women under 55 years of age. Br J Obstet Gynaecol. 1989 Jul;96(7):783–788. doi: 10.1111/j.1471-0528.1989.tb03316.x. [DOI] [PubMed] [Google Scholar]
  15. Yu M. C., Tong M. J., Govindarajan S., Henderson B. E. Nonviral risk factors for hepatocellular carcinoma in a low-risk population, the non-Asians of Los Angeles County, California. J Natl Cancer Inst. 1991 Dec 18;83(24):1820–1826. doi: 10.1093/jnci/83.24.1820. [DOI] [PubMed] [Google Scholar]

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