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British Journal of Experimental Pathology logoLink to British Journal of Experimental Pathology
. 1989 Apr;70(2):199–205.

Lipopolysaccharide-induced insulin resistance in monolayers of cultured hepatocytes.

M T Portolés 1, R Pagani 1, M J Ainaga 1, I Díaz-Laviada 1, A M Municio 1
PMCID: PMC2040547  PMID: 2659062

Abstract

In order to clarify the endotoxin effect on the hepatic removal of insulin, the influence of lipopolysaccharide (LPS) from E. coli 0111:B4 on the insulin binding and endocytosis in cultured hepatocytes from adult male rats has been investigated. LPS decreases both processes in a time and temperature-dependent manner, showing a major effect at short time and low temperature, according to the characteristics of LPS binding and uptake.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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