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British Journal of Experimental Pathology logoLink to British Journal of Experimental Pathology
. 1989 Oct;70(5):525–531.

Prostanoid release by macrophages at a distance from an inflammatory site.

M Tissot 1, S Strzalko 1, A Thuret 1, J P Giroud 1
PMCID: PMC2040592  PMID: 2818931

Abstract

During the development of an acute inflammatory reaction induced in the rat pleural cavity by dextran, calcium pyrophosphate, saline or phosphate buffered saline, macrophages present at a distant site (peritoneal cavity) display an increased capacity to release prostanoids: prostaglandins, prostacyclin and thromboxane. Enhanced levels of 6-keto-PGF1 alpha were observed both in peritoneal lavages (experiments in vivo) and in macrophage supernatants after 24-h culture (experiments in vitro). TXB2 levels were mainly increased in peritoneal lavages and PGE2 in culture supernatants. In vivo, levels of prostanoids in the peritoneal cavity reached a maximum 24 h after the induction of pleurisy whatever the injected substance. In vitro, amounts of arachidonic acid metabolites were highest in supernatants of cultured peritoneal macrophages harvested 72 h after the pleural injection of dextran or CaPP. These results show that the regulation of macrophage functions is closely related to prostanoid production, especially the release of PGE2 and PGI2.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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