Skip to main content
PMC home page
British Journal of Experimental Pathology logoLink to British Journal of Experimental Pathology
. 1982 Oct;63(5):562–572.

A spectrum of immune responses and pathological conditions between certain animal species to experimental Mycobacterium bovis infection.

C J Thorns, J A Morris, T W Little
PMCID: PMC2040755  PMID: 6756462

Abstract

Guinea-pigs, rabbits, rats, ferrets and hedgehogs were infected with a recent field isolate of Mycobacterium bovis. The cell-mediated and antibody responses were studied up to 8 weeks after infection at which time the animals were killed and pathological, histological and bacteriological examinations were carried out. Guinea-pigs and rabbits produced an intense cell-mediated response and strong tissue reactions around the lesions. This appears, in part, to be responsible for the susceptibility of these animals to M. bovis. The strong cell-mediated response was also related to the small numbers of organisms in the tissues. Ferrets produced very little cell-mediated response and only minor tissue reactions. The lack of any cell-mediate response was related to the large numbers of organisms in the tissues which produced an acute disseminated disease. The antibody response produced by ferrets, rabbits and guinea-pigs was variable within an between the species and could not be related to numbers of organisms in the tissues. In rats and hedgehogs a specific cell-mediated and humoral response was difficult to detect but the growth of the organism was controlled by the host resulting in a persistent subclinical infection with no mortality.

Full text

PDF
563

Images in this article

568Fig. 3
on p.568
568Fig. 4
on p.568
569Fig. 5
on p.569
569Fig. 6
on p.569

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Brochier J. MLR-R and MLR-S gene products are expressed on different lymphoid cells. Transplantation. 1977 Jul;24(1):63–69. doi: 10.1097/00007890-197707000-00009. [DOI] [PubMed] [Google Scholar]
  2. Drexhage H. A., Blomberg-vd Flier B. M., vd Berg W. B. Studies on the effect of mycobacterial antibodies on skin-test reactivity to M. tuberculosis. Br J Exp Pathol. 1980 Apr;61(2):186–194. [PMC free article] [PubMed] [Google Scholar]
  3. Greaves M. F., Janossy G., Doenhoff M. Activation of human T and B lymphocytes by polyclonal mitogens. Nature. 1974 Apr 19;248(5450):698–701. doi: 10.1038/248698a0. [DOI] [PubMed] [Google Scholar]
  4. Himeno K., Nomoto K., Kuroiwa A., Miyazaki S., Takeya K. Relation between delayed skin reactivity and macrophage migration inhibition or lymphocyte transformation in tuberculin-type hypersensitivity and Jones-Mote hypersensitivity. Microbiol Immunol. 1977;21(2):99–110. doi: 10.1111/j.1348-0421.1977.tb02812.x. [DOI] [PubMed] [Google Scholar]
  5. LESSLIE I. W. A comparison of biological and some cultural methods for the primary isolation of Mycobacterium tuberculosis. J Comp Pathol. 1959 Jan;69(1):1–10. doi: 10.1016/s0368-1742(59)80001-1. [DOI] [PubMed] [Google Scholar]
  6. Lenzini L., Rottoli P., Rottoli L. The spectrum of human tuberculosis. Clin Exp Immunol. 1977 Feb;27(2):230–237. [PMC free article] [PubMed] [Google Scholar]
  7. Mackaness G. B. Resistance to intracellular infection. J Infect Dis. 1971 Apr;123(4):439–445. doi: 10.1093/infdis/123.4.439. [DOI] [PubMed] [Google Scholar]
  8. Mackaness G. B. The immunology of antituberculous immunity. Am Rev Respir Dis. 1968 Mar;97(3):337–344. doi: 10.1164/arrd.1968.97.3.337. [DOI] [PubMed] [Google Scholar]
  9. Morris J. A., Stevens A. E., Little T. W., Stuart P. Lymphocyte unresponsiveness to PPD tuberculin in badgers infected with Mycobacterium bovis. Res Vet Sci. 1978 Nov;25(3):390–392. [PubMed] [Google Scholar]
  10. PEARMAIN G., LYCETTE R. R., FITZGERALD P. H. Tuberculin-induced mitosis in peripheral blood leucocytes. Lancet. 1963 Mar 23;1(7282):637–638. doi: 10.1016/s0140-6736(63)91275-3. [DOI] [PubMed] [Google Scholar]
  11. PULLING F. B. An outbreak of bovine tuberculosis in mink and treatment with rimifon. J Am Vet Med Assoc. 1952 Nov;121(908):389–390. [PubMed] [Google Scholar]
  12. Rook G. A., Stanford J. L. The relevance to protection of three forms of delayed skin-test response evoked by m. leprae and other mycobacteria in mice. Correlation with the classical work in the guinea-pig. Parasite Immunol. 1979 Summer;1(2):111–123. doi: 10.1111/j.1365-3024.1979.tb00699.x. [DOI] [PubMed] [Google Scholar]
  13. Rosenstreich D. L., Rosenthal A. S. Peritoneal exudate lymphocyte. 3. Dissociation of antigen-reactive lymphocytes from antigen-binding cells in a T lymphocyte enriched population in the guinea pig. J Immunol. 1974 Mar;112(3):1085–1093. [PubMed] [Google Scholar]
  14. Roupe G., Strannegård O. The influence of antibody on the induction and elicitation of allergic contact dermatitis. Int Arch Allergy Appl Immunol. 1972;43(5):691–699. doi: 10.1159/000230885. [DOI] [PubMed] [Google Scholar]
  15. Seeger R. C., Oppenheim J. J. Synergistic interaction of macrophages and lymphocytes in antigen-induced transformation of lymphocytes. J Exp Med. 1970 Jul 1;132(1):44–65. doi: 10.1084/jem.132.1.44. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Thoen C. O., Richards W. D., Jarnagin J. L. Mycobacteria isolated from exotic animals. J Am Vet Med Assoc. 1977 May 1;170(9):987–990. [PubMed] [Google Scholar]
  17. Turk J. L., Bryceson A. D. Immunological phenomena in leprosy and related diseases. Adv Immunol. 1971;13:209–266. doi: 10.1016/s0065-2776(08)60185-6. [DOI] [PubMed] [Google Scholar]
  18. Weksler M. E., Kuntz M. M. Synergy between human T and B lymphocytes in their response to phythaemagglutinin and pokeweed mitogen. Immunology. 1976 Aug;31(2):273–281. [PMC free article] [PubMed] [Google Scholar]

Articles from British journal of experimental pathology are provided here courtesy of Wiley

RESOURCES