Abstract
Carrageenan toxicity was found to vary according to the biochemical nature and source of material injected. Ischaemic lesions of body extremities (acronecrosis) were produced by some but not all preparations. Histological examination of these sites and of both recent and old organ lesions (especially of liver and kidney) confirmed that the underlying pathology was disseminated intravascular coagulation. Evidence was also obtained that carrageenans are hepatotoxic.
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- Aschheim L., Raffel S. The immunodepressant effect of carrageenin. J Reticuloendothel Soc. 1972 Mar;11(3):253–262. [PubMed] [Google Scholar]
- Bice D. E., Gruwell D. G., Salvaggio J. E., Hoffmann E. O. Suppression of primary immunization by carrageenan - a macrophage toxic agent. Immunol Commun. 1972;1(6):615–625. doi: 10.3109/08820137209022968. [DOI] [PubMed] [Google Scholar]
- Bice D., Schwartz H. J., Lake W. W., Salvaggio J. The effect of carrageenan on the establishment of delayed hypersensitivity. Int Arch Allergy Appl Immunol. 1971;41(4):628–636. doi: 10.1159/000230555. [DOI] [PubMed] [Google Scholar]
- Catanzaro P. J., Schwartz H. J., Graham R. C., Jr Spectrum and possible mechanism of carrageenan cytotoxicity. Am J Pathol. 1971 Aug;64(2):387–404. [PMC free article] [PubMed] [Google Scholar]
- Di Rosa M. Biological properties of carrageenan. J Pharm Pharmacol. 1972 Feb;24(2):89–102. doi: 10.1111/j.2042-7158.1972.tb08940.x. [DOI] [PubMed] [Google Scholar]
- LENDRUM A. C., FRASER D. S., SLIDDERS W., HENDERSON R. Studies on the character and staining of fibrin. J Clin Pathol. 1962 Sep;15:401–413. doi: 10.1136/jcp.15.5.401. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Schwartz H. J., Kellermeyer R. W. Carrageenan and delayed hypersensitivity. II. Activation of Hageman factor by carrageenan and its possible significance. Proc Soc Exp Biol Med. 1969 Dec;132(3):1021–1024. doi: 10.3181/00379727-132-34358. [DOI] [PubMed] [Google Scholar]
- Thomson A. W., Horne C. H. Failure of carrageenan to affect graft-versus-host reactivity in the rat. Transplantation. 1975 Nov;20(5):435–437. [PubMed] [Google Scholar]
- Thomson A. W., Wilson A. R., Cruickshank W. J., Horne C. H. Evaluation of carrageenan as an immunosuppressive agent and mediator of intravascular coagulation. Biomedicine. 1976 May;24(2):102–106. [PubMed] [Google Scholar]