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British Journal of Experimental Pathology logoLink to British Journal of Experimental Pathology
. 1977 Dec;58(6):644–652.

Changes in whole blood and serum components during Francisella tularensis and rabbit pox infections of rabbits.

P Hambleton, P W Harris-Smith, N E Bailey, R E Strange
PMCID: PMC2041297  PMID: 204323

Abstract

Rabbits infected with virulent Francisella tularensis strain Schu S4 or rabbit pox virus (Utrecht strain) showed significant early changes in serum levels of trace metals, neutral fat and alkaline phosphatase activity. With F. tularensis infections a marked early leukopenia and a decrease in serum amino acids were also observed; the effect on amino acid levels was less pronounced in rabbit pox infections. In both diseases these changes preceded the appearance of acute phase globulins in the serum. Vaccination with the live vaccine strain of F. tularensis slightly increased survival times but did not delay the onset of metabolic changes in rabbits subsequently infected with the virulent Schu S4 strain.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Baskerville A., Hambleton P. Pathogenesis and pathology of respiratory tularaemia in the rabbit. Br J Exp Pathol. 1976 Jun;57(3):339–347. [PMC free article] [PubMed] [Google Scholar]
  2. Beisel W. R., Sawyer W. D., Ryll E. D., Crozier D. Metabolic effects of intracellular infections in man. Ann Intern Med. 1967 Oct;67(4):744–779. doi: 10.7326/0003-4819-67-4-744. [DOI] [PubMed] [Google Scholar]
  3. Berendt R. F., Long G. G., Abeles F. B., Canonico P. G., Elwell M. R., Powanda M. C. Pathogenesis of respiratory Klebsiella pneumoniae infection in rats: bacteriological and histological findings and metabolic alterations. Infect Immun. 1977 Feb;15(2):586–593. doi: 10.1128/iai.15.2.586-593.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Canonico P. G., Powanda M. C., Cockerell G. L., Moe J. B. Relationship of serum beta-glucuronidase and lysozyme to pathogenesis of tularemia in immune and nonimmune rats. Infect Immun. 1975 Jul;12(1):42–47. doi: 10.1128/iai.12.1.42-47.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Dingjan P. G., Jongeneel J., Postma T., Stroes J. A. Evaluation of the determination of alanine naphthylamidase isoenzymes by agar and polyacrylamide disc electrophoresis for the diagnosis of pancreatic diseases. Clin Chim Acta. 1973 Dec 12;49(2):215–224. doi: 10.1016/0009-8981(73)90294-5. [DOI] [PubMed] [Google Scholar]
  6. Downs C. M., Coriell L. L., Chapman S. S., Klauber A. The Cultivation of Bacterium tularense in Embryonated Eggs. J Bacteriol. 1947 Jan;53(1):89–100. [PMC free article] [PubMed] [Google Scholar]
  7. EIGELSBACH H. T., BRAUN W., HERRING R. D. Studies on the variation of Bacterium tularense. J Bacteriol. 1951 May;61(5):557–569. doi: 10.1128/jb.61.5.557-569.1951. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. EIGELSBACH H. T., DOWNS C. M. Prophylactic effectiveness of live and killed tularemia vaccines. I. Production of vaccine and evaluation in the white mouse and guinea pig. J Immunol. 1961 Oct;87:415–425. [PubMed] [Google Scholar]
  9. Eddington C. L., Upchurch H. F., Kampschmidt R. F. Effect of extracts from rabbit leukocytes on levels of acute phase globulins in rat serum. Proc Soc Exp Biol Med. 1971 Jan;136(1):159–164. doi: 10.3181/00379727-136-35217. [DOI] [PubMed] [Google Scholar]
  10. Feigin R. D., Dangerfield H. G. Whole blood amino acid changes following respiratory-acquired Pasteurella tularensis infection in man. J Infect Dis. 1967 Oct;117(4):346–351. doi: 10.1093/infdis/117.4.346. [DOI] [PubMed] [Google Scholar]
  11. Feigin R. D., Jaeger R. F., McKinney R. W., Alevizatos A. C. Live, attenuated Venezuelan equine encephalomyelitis virus vaccine. II. Whole-blood amino-acid and fluorescent-antibody studies following immunization. Am J Trop Med Hyg. 1967 Nov;16(6):769–777. [PubMed] [Google Scholar]
  12. Feigin R. D., Klainer A. S., Beisel W. R., Hornick R. B. Whole-blood amino acids in experimentally induced typhoid fever in man. N Engl J Med. 1968 Feb 8;278(6):293–298. doi: 10.1056/NEJM196802082780602. [DOI] [PubMed] [Google Scholar]
  13. Kampschmidt R. F., Upchurch H. F. A comparison of the effects of rabbit endogenous pyrogen on the body temperature of the rabbit and lowering of plasma iron in the rat. Proc Soc Exp Biol Med. 1970 Jan;133(1):128–130. doi: 10.3181/00379727-133-34423. [DOI] [PubMed] [Google Scholar]
  14. Kampschmidt R. F., Upchurch H. F. The effect of endogenous pyrogen on the plasma zinc concentration of the rat. Proc Soc Exp Biol Med. 1970 Sep;134(4):1150–1152. doi: 10.3181/00379727-134-34962. [DOI] [PubMed] [Google Scholar]
  15. Nutter J. E., Myrvik Q. N. In vitro interactions between rabbit alveolar macrophages and Pasteurella tularensis. J Bacteriol. 1966 Sep;92(3):645–651. doi: 10.1128/jb.92.3.645-651.1966. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Pekarek R. S., Beisel W. R. Characterization of the endogenous mediator(s) of serum zinc and iron depression during infection and other stresses. Proc Soc Exp Biol Med. 1971 Nov;138(2):728–732. doi: 10.3181/00379727-138-35977. [DOI] [PubMed] [Google Scholar]
  17. Pekarek R. S., Wannemacher R. W., Jr, Beisel W. R. The effect of leukocytic endogenous mediator (LEM) on the tissue distribution of zinc and iron. Proc Soc Exp Biol Med. 1972 Jun;140(2):685–688. doi: 10.3181/00379727-140-36531. [DOI] [PubMed] [Google Scholar]
  18. Powanda M. C., Cockerell G. L., Moe J. B., Abeles F. B., Pekarek R. S., Canonico P. G. Induced metabolic sequelae of tularemia in the rat: correlation with tissue damage. Am J Physiol. 1975 Aug;229(2):479–483. doi: 10.1152/ajplegacy.1975.229.2.479. [DOI] [PubMed] [Google Scholar]
  19. Powanda M. C., Cockerell G. L., Pekarek R. S. Amino acid and zinc movement in relation to protein synthesis early in inflammation. Am J Physiol. 1973 Aug;225(2):399–401. doi: 10.1152/ajplegacy.1973.225.2.399. [DOI] [PubMed] [Google Scholar]
  20. Powanda M. C., Kenyon R. H., Moe J. B. Alterations in plasma copper, zinc, amino acids, and seromucoid during Rocky Moutain spotted fever in guinea pigs. Proc Soc Exp Biol Med. 1976 Apr;151(4):804–807. doi: 10.3181/00379727-151-39311. [DOI] [PubMed] [Google Scholar]
  21. Sammons L. S., Kenyon R. H., Burger G. T., Pedersen C. E., Jr, Spertzel R. O. Changes in blood serum constituents and hematologic values in Macaca mulatta with Rocky Mountain spotted fever. Am J Vet Res. 1976 Jun;37(6):725–730. [PubMed] [Google Scholar]
  22. Scharer J. M., Klein F., Lincoln R. E. Growth and metabolism of live vaccine strain of Pasteurella tularensis. Appl Microbiol. 1968 Jun;16(6):855–861. doi: 10.1128/am.16.6.855-861.1968. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Strange R. E., Benbough J. E., Hambleton P., Martin K. L. Methods for the assessment of microbial populations recovered from enclosed aerosols. J Gen Microbiol. 1972 Aug;72(1):117–125. doi: 10.1099/00221287-72-1-117. [DOI] [PubMed] [Google Scholar]
  24. TIGERTT W. D. Soviet viable Pasteurella tularensis vaccines. A review of selected articles. Bacteriol Rev. 1962 Sep;26:354–373. doi: 10.1128/br.26.3.354-373.1962. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Wannemacher R. W., Jr, DuPont H. L., Pekarek R. S., Powanda M. C., Schwartz A., Hornick R. B., Beisel W. R. An endogenous mediator of depression of amino acids and trace metals in serum during typhoid fever. J Infect Dis. 1972 Jul;126(1):77–86. doi: 10.1093/infdis/126.1.77. [DOI] [PubMed] [Google Scholar]
  26. Wannemacher R. W., Jr, Klainer A. S., Dinterman R. E., Beisel W. R. The significance and mechanism of an increased serum phenylalanine-tyrosine ratio during infection. Am J Clin Nutr. 1976 Sep;29(9):997–1006. doi: 10.1093/ajcn/29.9.997. [DOI] [PubMed] [Google Scholar]
  27. Wannemacher R. W., Jr, Pekarek R. S., Beisel W. R. Mediator of hepatic amino acid flux in infected rats. Proc Soc Exp Biol Med. 1972 Jan;139(1):128–132. doi: 10.3181/00379727-139-36094. [DOI] [PubMed] [Google Scholar]
  28. Wannemacher R. W., Jr, Pekarek R. S., Klainer A. S., Bartelloni P. J., Dupont H. L., Hornick R. B., Beisel W. R. Detection of a leukocytic endogenous mediator-like mediator of serum amino acid and zinc depression during various infectious illnesses. Infect Immun. 1975 Apr;11(4):873–875. doi: 10.1128/iai.11.4.873-875.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Wannemacher R. W., Jr, Pekarek R. W., Bartelloni P. J., Vollmer R. T., Beisel W. R. Changes in individual plasma amino acids following experimentally induced and fly fever virus infection. Metabolism. 1972 Jan;21(1):67–76. doi: 10.1016/0026-0495(72)90021-2. [DOI] [PubMed] [Google Scholar]

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