Abstract
The haemodynamic changes following partial hepatectomy (PH) in the portacavally transposed rat have been studied using an 85Kr clearance technique. Liver blood flow measurements (LBF) were made before and after portacaval transposition (PCT) and PH was performed either immediately or at 3 weeks after transposition and further blood flow measurements made. No change in LBF was noted after PCT compared with preoperative values. Following PH in the portacavally transposed animals there was no marked increase in LBF. It is suggested that the liver atrophy consequent on portal diversion is due to deviation factors in portal blood and not to a decrease in absolute LBF. Regenerative hyperplasia occurs in the absence of the post-hepatectomy rise in LBF seen in normal animals.
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- Guest J., Ryan C. J., Benjamin I. S., Blumgart L. H. Portacaval transposition and subsequent partial hepatectomy in the rat: effects on liver atrophy, hypertrophy and regenerative hyperplasia. Br J Exp Pathol. 1977 Apr;58(2):140–146. [PMC free article] [PubMed] [Google Scholar]
- Hyde T. A., Davis J. C. The effects of cortisol and chlorazanil on the mitotic rate in mouse liver and skin. Eur J Cancer. 1966 Aug;2(3):227–230. doi: 10.1016/0014-2964(66)90058-2. [DOI] [PubMed] [Google Scholar]
- JAFFE J. J. Diurnal mitotic periodicity in regenerating rat liver. Anat Rec. 1954 Dec;120(4):935–954. doi: 10.1002/ar.1091200408. [DOI] [PubMed] [Google Scholar]
- Lee S., Broelsch C. E., Chandler J. G., Charters A. C., 3rd, Orloff M. J. Liver regeneration following portacaval transposition in rats. Surg Forum. 1974;25(0):391–394. [PubMed] [Google Scholar]
- Mathie R. T., Leiberman D. P., Harper A. M., Blumgart L. H. The solubility of 85Krypton in the regenerating liver of the rat. Br J Exp Pathol. 1977 Jun;58(3):231–235. [PMC free article] [PubMed] [Google Scholar]
- Rice G. C., Leiberman D. P., Mathie R. T., Ryan C. J., Harper A. M., Blumgart L. H. Liver tissue blood flow measured by 85Kr clearance in the anaesthetized rat before and after partial hepatectomy. Br J Exp Pathol. 1977 Jun;58(3):243–250. [PMC free article] [PubMed] [Google Scholar]
- Rice G. C., Ryan C. J., Leiberman D. P., Mathie R. T., McGhee E., Harper A. M., Blumgart L. H. Measurement of liver blood flow in the rat using an 85Krypton clearance technique. Br J Exp Pathol. 1977 Jun;58(3):236–242. [PMC free article] [PubMed] [Google Scholar]
- Ryan C. J., Benjamin I. S., Blumgart L. H. Portacaval transposition in the rat: a new technique and its effects on liver and body weight. Br J Surg. 1974 Mar;61(3):224–228. doi: 10.1002/bjs.1800610313. [DOI] [PubMed] [Google Scholar]
- Ryan C. J., Guest J., Ryan S., Harper A. M., Blumgart L. H. Hepatic blood flow studies in the rat before and after portacaval transposition. Br J Exp Pathol. 1978 Feb;59(1):8–12. [PMC free article] [PubMed] [Google Scholar]
- Starzl T. E., Porter K. A., Kashiwagi N. Portal hepatotrophic factors, diabetes mellitus and acute liver atrophy, hypertrophy and regeneration. Surg Gynecol Obstet. 1975 Dec;141(6):843–858. [PMC free article] [PubMed] [Google Scholar]
- Starzl T. E., Watanabe K., Porter K. A., Putnam C. W. Effects of insulin, glucagon, and insuling/glucagon infusions on liver morphology and cell division after complete portacaval shunt in dogs. Lancet. 1976 Apr 17;1(7964):821–825. doi: 10.1016/s0140-6736(76)90477-3. [DOI] [PubMed] [Google Scholar]
- WEINBREN K. Regeneration of the liver. Gastroenterology. 1959 Nov;37:657–678. [PubMed] [Google Scholar]