Abstract
The surfaces of vegetations in the first 24 h after initiation of experimental streptococcal endocarditis in rabbits were examined systematically using the scanning electron microscope (SEM). Most of the observed fields were occupied by amorphous material but with the SEM very small features of interest could be identified. Erythrocytes were more frequent before 6 h and leukocytes were rarely seen. Bacteria were significantly more frequent at 10/15 min and at 20 h. It is suggested that bacteria lodge on the vegetation surface following inoculation and that after a lag phase colonies are formed within the vegetation which reach the surface again at about 20 h.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Durack D. T., Beeson P. B. Experimental bacterial endocarditis. I. Colonization of a sterile vegetation. Br J Exp Pathol. 1972 Feb;53(1):44–49. [PMC free article] [PubMed] [Google Scholar]
- Durack D. T., Beeson P. B. Experimental bacterial endocarditis. II. Survival of a bacteria in endocardial vegetations. Br J Exp Pathol. 1972 Feb;53(1):50–53. [PMC free article] [PubMed] [Google Scholar]
- Durack D. T., Beeson P. B., Petersdorf R. G. Experimental bacterial endocarditis. 3. Production and progress of the disease in rabbits. Br J Exp Pathol. 1973 Apr;54(2):142–151. [PMC free article] [PubMed] [Google Scholar]
- Garrison P. K., Freedman L. R. Experimental endocarditis I. Staphylococcal endocarditis in rabbits resulting from placement of a polyethylene catheter in the right side of the heart. Yale J Biol Med. 1970 Jun;42(6):394–410. [PMC free article] [PubMed] [Google Scholar]
- Hardie J. M., Bowden G. H. Cell wall and serological studies on Streptococcus mutans. Caries Res. 1974;8(4):301–316. doi: 10.1159/000260120. [DOI] [PubMed] [Google Scholar]
- McGowan D. A. Scanning electron microscopy of heart-valve vegetations. Lancet. 1977 Oct 15;2(8042):822–822. doi: 10.1016/s0140-6736(77)90757-7. [DOI] [PubMed] [Google Scholar]
- Pelletier L. L., Jr, Durack D. T., Petersdorf R. G. Chemotherapy of experimental streptococcal endocarditis. IV. Further observations on prophylaxis. J Clin Invest. 1975 Aug;56(2):319–330. doi: 10.1172/JCI108096. [DOI] [PMC free article] [PubMed] [Google Scholar]