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British Journal of Experimental Pathology logoLink to British Journal of Experimental Pathology
. 1980 Apr;61(2):124–131.

Benign leptospirosis: the pathology of experimental infection of monkeys with Leptospira interrogans serovars balcanica and tarassovi.

R B Marshall, A BAskerville, P Hambleton, G D Adams
PMCID: PMC2041522  PMID: 6775660

Abstract

Grivet monkeys experimentally infected with Leptospira interrogans serovars balcanica and tarassovi showed no clinical disease, but severe meningoencephalitis was demonstrated histologically in animals killed 26 and 33 days after infection. The meningeal and perivascular reactions were exclusively lymphocytic. Mild focal lesions of degeneration and cellular infiltration were also present in the kidneys and femoral musculature.

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Selected References

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  1. AREAN V. M. The pathologic anatomy and pathogenesis of fatal human leptospirosis (Weil's disease). Am J Pathol. 1962 Apr;40:393–423. [PMC free article] [PubMed] [Google Scholar]
  2. Avery T. L. Letter: Leptospirosis hardjo. N Z Med J. 1976 Mar 24;83(560):208–208. [PubMed] [Google Scholar]
  3. BEESON P. B., HANKEY D. D. Leptospiral meningitis. AMA Arch Intern Med. 1952 Apr;89(4):575–583. doi: 10.1001/archinte.1952.00240040054007. [DOI] [PubMed] [Google Scholar]
  4. Berman S. J., Tsai C. C., Holmes K., Fresh J. W., Watten R. H. Sporadic anicteric leptospirosis in South Vietnam. A study in 150 patients. Ann Intern Med. 1973 Aug;79(2):167–173. doi: 10.7326/0003-4819-79-2-167. [DOI] [PubMed] [Google Scholar]
  5. Christmas B. W., Bragger J. M., Till D. G. Dairy farm fever in New Zealand: isolation of L pomona and L hardjo from a local outbreak. N Z Med J. 1974 May 8;79(514):904–906. [PubMed] [Google Scholar]
  6. Christmas B. W., Tennent R. B., Lindsay P. G. Dairy farm fever in New Zealand: a local outbreak of human leptospirosis. N Z Med J. 1974 May 8;79(514):901–904. [PubMed] [Google Scholar]
  7. Cole J. R., Jr, Sulzer C. R., Pursell A. R. Improved microtechnique for the leptospiral microscopic agglutination test. Appl Microbiol. 1973 Jun;25(6):976–980. doi: 10.1128/am.25.6.976-980.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. DEBRITO T., FREYMUELLER E., PENNA D. O., SANTOS H. S., DEALMEIDA S. S., AYROZAGALVAO P. A., PEREIRA V. G. ELECTRON MICROSCOPY OF THE BIOPSIED KIDNEY IN HUMAN LEPTOSPIROSIS. Am J Trop Med Hyg. 1965 May;14:397–403. doi: 10.4269/ajtmh.1965.14.397. [DOI] [PubMed] [Google Scholar]
  9. Fenske E., Fenske G., Oberdoerster F. Vom Schwein erworbene menschliche Leptospireninfektionen in der DDR. Z Gesamte Hyg. 1969 Aug;15(8):577–585. [PubMed] [Google Scholar]
  10. Fraser D. W., Glosser J. W., Francis D. P., Phillips C. J., Feeley J. C., Sulzer C. R. Leptospirosis caused by serotype Fort-Bragg. A suburban outbreak. Ann Intern Med. 1973 Dec;79(6):786–789. doi: 10.7326/0003-4819-79-6-786. [DOI] [PubMed] [Google Scholar]
  11. Hutchison J. H., Pippard J. S., Gleeson-White M. H., Sheehan H. L. Outbreak of Weil's Disease in the British Army in Italy. Br Med J. 1946 Jan 19;1(4437):81–83. [PMC free article] [PubMed] [Google Scholar]
  12. Keenan K. P., Alexander A. D., Mongomery C. A., Jr Pathogenesis of experimental Leptospira interrogans, serovar bataviae, infection in the dog: microbiological, clinical, hematologic, and biochemical studies. Am J Vet Res. 1978 Mar;39(3):449–454. [PubMed] [Google Scholar]
  13. LEVRAT M., DESPIERRES G., OLLAGNIER C., LANTERNIER Les manifestations pulmonaires de la spirochétose ictéro-hémorragique. Lyon Med. 1950 Jul 2;183(27):7–9. [PubMed] [Google Scholar]
  14. McINTYRE W. I. M., MONTGOMERY G. L. Renal lesions in Leptospira canicola infection in dogs. J Pathol Bacteriol. 1952 Jan;64(1):145–160. doi: 10.1002/path.1700640115. [DOI] [PubMed] [Google Scholar]
  15. Michna S. W., Campbell R. S. Leptospirosis in pigs: epidemiology, microbiology and pathology. Vet Rec. 1969 Feb 8;84(6):135–138. doi: 10.1136/vr.84.6.135. [DOI] [PubMed] [Google Scholar]
  16. Minette H. P., Shaffer M. F. Experimental leptospirosis in monkeys. Am J Trop Med Hyg. 1968 Mar;17(2):202–212. doi: 10.4269/ajtmh.1968.17.202. [DOI] [PubMed] [Google Scholar]
  17. RISTIC M., GALTON M. M., MCRAE L., SANDERS D. A., STEELE J. H. Experimental leptospirosis in bovines. I. Establishment of infection with Leptospira sejroe. J Infect Dis. 1957 May-Jun;100(3):228–240. doi: 10.1093/infdis/100.3.228. [DOI] [PubMed] [Google Scholar]
  18. SEILER H. E., NORVAL J., COGHLAN J. D. Leptospirosis in piggery workers. Nature. 1956 Jun 2;177(4518):1042–1042. doi: 10.1038/1771042a0. [DOI] [PubMed] [Google Scholar]
  19. Taylor P. L., Hanson L. E., Simon J. Serologic, pathologic, and immunologic features of experimentally induced leptospiral nephritis in dogs. Am J Vet Res. 1970 Jun;31(6):1033–1049. [PubMed] [Google Scholar]
  20. Young B. J. A reliable method for demonstrating spirochaetes in tissue sections. J Med Lab Technol. 1969 Jul;26(3):248–252. [PubMed] [Google Scholar]

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