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British Journal of Experimental Pathology logoLink to British Journal of Experimental Pathology
. 1980 Aug;61(4):415–420.

Histopathological changes in the lungs of influenza-infected mice superinfected with Staphylococcus aureus.

I D Gardner, T M Kung
PMCID: PMC2041600  PMID: 6252936

Abstract

Histopathological changes in the lung were assessed in a model infection of mice using swine influenza virus and Staphylococcus aureus. Virus preinfection markedly enhanced both the persistence of S. aureus and the extent and duration of the inflammatory response. Lymphocytic infiltration was increased and regeneration and squamous metaplasia were delayed, suggesting an enhancement of an immunopathological response to the virus. Mice with the dual infection showed a decrease in phagocytic cell infiltration of the lung compared to that observed in those with the bacterial infection only, and this may reflect a decline in alveolar macrophage function after influenza infection.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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