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. 1980 Mar;68(3):585–592. doi: 10.1111/j.1476-5381.1980.tb14574.x

A demonstration of naloxone-precipitated opiate withdrawal on single neurones in the morphine-tolerant/dependent rat brain.

J P Fry, A Herz, W Zieglgänsberger
PMCID: PMC2044191  PMID: 6132637

Abstract

1 A comparison has been made between the effects of microelectrophoretically applied naloxone on single neurones in the frontal cerebral cortex and the striatum of naive and of morphine-tolerant/dependent rats, anaesthetized with a mixture of alpha-chloralose and urethane. 2 Specificity of the results obtained was evaluated by contrasting the effects of alternate applications of the (+)- and (-)-isomers of naloxone to the same neurones. 3 In naive rats naloxone had predominantly no effect, only a few cells revealing non-specific depressant responses to the drug. 4 In morphine-tolerant/dependent rats a higher proportion of neurones responded to naloxone; either with stereospecific excitatory responses, in which the activity evoked by L-glutamate or acetylcholine was increased, or with a non-specific inhibition, similar to that observed in naive animals. 5 It is suggested that these excitatory responses to microelectrophoretically applied (-)-naloxone represent opiate withdrawal responses at the single neurone level and that they reflect a latent hyperexcitability of the postsynaptic membrane in the morphine-tolerant/dependent state.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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