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. 1980 Apr;68(4):633–636. doi: 10.1111/j.1476-5381.1980.tb10854.x

An in vitro study of various drugs on central and peripheral airways of the rat: a comparison with human airways.

K M Lulich, J W Paterson
PMCID: PMC2044239  PMID: 7378638

Abstract

1 The effect of histamine and other drugs on the central and peripheral airways of the rat was studied by applying them directly to isolated tracheal and lung strip preparations. These effects were then compared with those observed on human isolated bronchial muscle preparations. 2 Acetylcholine and 5-hydroxytryptamine (5-HT) both contracted the lung strip and trachea of the rat, and both were more potent on the trachea than the lung strip. 3 Histamine and prostaglandins E2 (PGF2) or F2 tau (PGF2 tau) produced no effect on either the lung strip or trachea of the rat. 4 On the human isolated bronchial preparation, in contrast to the rat airways, both histamine and PGF2 tau produced marked concentration-dependent contractions and 5-HT either produced no response or a slight relaxation. 5 In view of these results, the use of anaphylactic bronchoconstriction in the rat as a model for the study of asthma in man is questioned.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. AKCASU A. The actions of drugs on the isolated trachea. J Pharm Pharmacol. 1952 Sep;4(9):671–671. doi: 10.1111/j.2042-7158.1952.tb13199.x. [DOI] [PubMed] [Google Scholar]
  2. Austen K. F., Orange R. P. Bronchial asthma: the possible role of the chemical mediators of immediate hypersensitivity in the pathogenesis of subacute chronic disease. Am Rev Respir Dis. 1975 Sep;112(3):423–436. doi: 10.1164/arrd.1975.112.3.423. [DOI] [PubMed] [Google Scholar]
  3. Brocklehurst W. E. The pharmacology of asthma and possible therapeutic developments. Ciba Found Study Group. 1971;38:132–150. [PubMed] [Google Scholar]
  4. Burns J. W., Doe J. E. A comparison of drug-induced responses on rat tracheal, bronchial and lung strip in vitro preparations. Br J Pharmacol. 1978 Sep;64(1):71–74. doi: 10.1111/j.1476-5381.1978.tb08642.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Carney I. F. IgE-mediated anaphylactic bronchoconstriction in the guinea pig and the effect of disodium cromoglycate. Int Arch Allergy Appl Immunol. 1976;50(3):322–328. doi: 10.1159/000231509. [DOI] [PubMed] [Google Scholar]
  6. Church M. K., Collier H. O., James G. W. The inhibition by dexamethasone and disodium cromoglycate of anaphylactic bronchoconstriction in the rat. Br J Pharmacol. 1972 Sep;46(1):56–65. doi: 10.1111/j.1476-5381.1972.tb06848.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Church M. K. Response of rat lung to humoral mediators of anaphylaxis and its modification by drugs and sensitization. Br J Pharmacol. 1975 Nov;55(3):423–430. doi: 10.1111/j.1476-5381.1975.tb06947.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Drazen J. M., Austen K. F. Effects of intravenous administration of slow-reacting substance of anaphylaxis, histamine, bradykinin, and prostaglandin F2alpha on pulmonary mechanics in the guinea pig. J Clin Invest. 1974 Jun;53(6):1679–1685. doi: 10.1172/JCI107719. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Farmer J. B., Richards I. M., Sheard P., Woods A. M. Mediators of passive lung anaphylaxis in the rat. Br J Pharmacol. 1975 Sep;55(1):57–64. doi: 10.1111/j.1476-5381.1975.tb07610.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Lulich K. M., Mitchell H. W., Sparrow M. P. The cat lung strip as an in vitro preparation of peripheral airways: a comparison of beta-adrenoceptor agonists, autacoids and anaphylactic challenge on the lung strip and trachea. Br J Pharmacol. 1976 Sep;58(1):71–79. doi: 10.1111/j.1476-5381.1976.tb07694.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Persson G. A., Ekman M. Contractile effects of histamine in large and small respiratory airways. Agents Actions. 1976 Jul;6(4):389–393. doi: 10.1007/BF01973208. [DOI] [PubMed] [Google Scholar]
  12. Piper P. J., Vane J. R. Release of additional factors in anaphylaxis and its antagonism by anti-inflammatory drugs. Nature. 1969 Jul 5;223(5201):29–35. doi: 10.1038/223029a0. [DOI] [PubMed] [Google Scholar]
  13. Piper P. J., Walker J. L. The release of spasmogenic substances from human chopped lung tissue and its inhibition. Br J Pharmacol. 1973 Feb;47(2):291–304. doi: 10.1111/j.1476-5381.1973.tb08327.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Porter G. A. Unanswered Questions About Tubulo-interstitial Nephropathies. West J Med. 1980 Feb;132(2):150–151. [PMC free article] [PubMed] [Google Scholar]

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