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. 1980 Aug;69(4):675–677. doi: 10.1111/j.1476-5381.1980.tb07921.x

Anticoagulant effects of sulphated polysaccharides in normal and antithrombin III-deficient plasmas.

G Kindness, W F Long, F B Williamson
PMCID: PMC2044303  PMID: 6159941

Abstract

1 Comparison of the effects of sulphated polysaccharides on thrombin-induced clotting of normal and antithrombin III-deficient plasmas suggests the involvement of antithrombin III (AT III) in the anticoagulant activities of cellulose, dextran and xylan sulphates. 2 AT III appears to play little or no role in the anticoagulant activity of carrageenans.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Abildgaard U., Gravem K., Godal H. C. Assay of progressive antithrombin in plasma. Thromb Diath Haemorrh. 1970 Oct 31;24(1):224–229. [PubMed] [Google Scholar]
  2. Barrowcliffe T. W., Johnson E. A., Thomas D. Antithrombin III and heparin. Br Med Bull. 1978 May;34(2):143–150. doi: 10.1093/oxfordjournals.bmb.a071484. [DOI] [PubMed] [Google Scholar]
  3. Everson N. W., Stacey R. L., Bell P. R. Effect of lambda-carrageenan on the survival of rat heart transplants. Transplantation. 1977 Nov;24(5):393–394. doi: 10.1097/00007890-197711000-00015. [DOI] [PubMed] [Google Scholar]
  4. HAWKINS W. W., LEONARD V. G. Antipeptic and antithrombic properties of carrageenin. J Lab Clin Med. 1962 Oct;60:641–648. [PubMed] [Google Scholar]
  5. Kindness G., Long W. F., Williamson F. B., Boyd J. Effects of carrageenans on the aggregation of human blood platelets. Thromb Res. 1979;15(1-2):3–15. doi: 10.1016/0049-3848(79)90047-1. [DOI] [PubMed] [Google Scholar]
  6. Kindness G., Long W. F., Williamson F. B. Enhancement of antithrombin III activity by carrageenans. Thromb Res. 1979;15(1-2):49–60. doi: 10.1016/0049-3848(79)90051-3. [DOI] [PubMed] [Google Scholar]
  7. Kindness G., Long W. F., Williamson F. B. Evidence for antithrombin III involvement in the anticoagulant activity of cellulose sulphate. Br J Pharmacol. 1980 Apr;68(4):645–649. doi: 10.1111/j.1476-5381.1980.tb10856.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Kindness G., Williamson F. B., Long W. F. Inhibition by antithrombin III of carrageenan- and xylan SP54-induced aggregation of human blood platelets [proceedings]. Biochem Soc Trans. 1980 Feb;8(1):84–85. doi: 10.1042/bst0080084. [DOI] [PubMed] [Google Scholar]
  9. Kindness G., Williamson F. B., Long W. F. Synergistic inhibition by antithrombin III and heparin-like compounds of thrombin-induced platelet aggregation [proceedings]. Biochem Soc Trans. 1980 Feb;8(1):85–86. doi: 10.1042/bst0080085. [DOI] [PubMed] [Google Scholar]
  10. Mackie M., Bennett B., Ogston D., Douglas A. S. Familial thrombosis: inherited deficiency of antithrombin III. Br Med J. 1978 Jan 21;1(6106):136–138. doi: 10.1136/bmj.1.6106.136. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Mancini G., Carbonara A. O., Heremans J. F. Immunochemical quantitation of antigens by single radial immunodiffusion. Immunochemistry. 1965 Sep;2(3):235–254. doi: 10.1016/0019-2791(65)90004-2. [DOI] [PubMed] [Google Scholar]
  12. RATNOFF O. D. An accelerating property of plasma for the coagulation of fibrinogen by thrombin. J Clin Invest. 1954 Aug;33(8):1175–1182. doi: 10.1172/JCI102990. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Rosenberg R. D., Armand G., Lam L. Structure-function relationships of heparin species. Proc Natl Acad Sci U S A. 1978 Jul;75(7):3065–3069. doi: 10.1073/pnas.75.7.3065. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Teien A. N., Abildgaard U., Hök M. The anticoagulant effect of heparan sulfate and dermatan sulfate. Thromb Res. 1976 Jun;8(6):859–867. doi: 10.1016/0049-3848(76)90014-1. [DOI] [PubMed] [Google Scholar]

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