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. 1982 Nov;77(3):505–509. doi: 10.1111/j.1476-5381.1982.tb09324.x

Vasoactive intestinal polypeptide is more potent than prostaglandin E2 as a vasodilator and oedema potentiator in rabbit skin.

T J Williams
PMCID: PMC2044619  PMID: 6958342

Abstract

1 The 28 amino acid polypeptide, vasoactive intestinal polypeptide (VIP) induced increased local blood flow when injected intradermally in the rabbit. 2 VIP was found to be even more potent than prostaglandin E2 (PGE2) in increasing blood flow; VIP induced a significant effect at a 1 pmol dose. 3 VIP was shown to be poor in increasing microvascular permeability but very potent in enhancing local oedema induced by two substances which increase permeability, bradykinin and C5a des Arg. VIP was more potent than PGE2 as an oedema potentiator. 4 Indomethacin had no effect on oedema potentiation induced by VIP, suggesting that a release of endogenous prostaglandins was not involved. 5 These results support our hypothesis for the regulation of oedema formation by arteriolar vasodilators, although the observations do not exclude the possibility of additional regulation by agonist interaction in the region of the venule. 6 VIP may be involved in the physiological control of normal blood flow and in hyperaemia in some types of inflammatory reactions.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Amelang E., Prasad C. M., Raymond R. M., Grega G. J. Interactions among inflammatory mediators on edema formation in the canine forelimb. Circ Res. 1981 Aug;49(2):298–306. doi: 10.1161/01.res.49.2.298. [DOI] [PubMed] [Google Scholar]
  2. Bray M. A., Cunningham F. M., Ford-Hutchinson A. W., Smith M. J. Leukotriene B4: a mediator of vascular permeability. Br J Pharmacol. 1981 Mar;72(3):483–486. doi: 10.1111/j.1476-5381.1981.tb11000.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Bryant M. G., Polak M. M., Modlin I., Bloom S. R., Albuquerque R. H., Pearse A. G. Possible dual role for vasoactive intestinal peptide as gastrointestinal hormone and neurotransmitter substance. Lancet. 1976 May 8;1(7967):991–993. doi: 10.1016/s0140-6736(76)91863-8. [DOI] [PubMed] [Google Scholar]
  4. Cutz E., Chan W., Track N. S., Goth A., Said S. I. Release of vasoactive intestinal polypeptide in mast cells by histamine liberators. Nature. 1978 Oct 19;275(5681):661–662. doi: 10.1038/275661a0. [DOI] [PubMed] [Google Scholar]
  5. Drazen J. M., Austen K. F., Lewis R. A., Clark D. A., Goto G., Marfat A., Corey E. J. Comparative airway and vascular activities of leukotrienes C-1 and D in vivo and in vitro. Proc Natl Acad Sci U S A. 1980 Jul;77(7):4354–4358. doi: 10.1073/pnas.77.7.4354. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Higgs G. A., Salmon J. A., Spayne J. A. The inflammatory effects of hydroperoxy and hydroxy acid products of arachidonate lipoxygenase in rabbit skin. Br J Pharmacol. 1981 Oct;74(2):429–433. doi: 10.1111/j.1476-5381.1981.tb09988.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. José P. J., Forrest M. J., Williams T. J. Human C5a des Arg increases vascular permeability. J Immunol. 1981 Dec;127(6):2376–2380. [PubMed] [Google Scholar]
  8. Kopaniak M. M., Hay J. B., Movat H. Z. The effect of hyperemia on vascular permeability. Microvasc Res. 1978 Jan;15(1):77–82. doi: 10.1016/0026-2862(78)90007-9. [DOI] [PubMed] [Google Scholar]
  9. O'Dorisio M. S., O'Dorisio T. M., Cataland S., Balcerzak S. P. Vasoactive intestinal polypeptide as a biochemical marker for polymorphonuclear leukocytes. J Lab Clin Med. 1980 Oct;96(4):666–672. [PubMed] [Google Scholar]
  10. Peck M. J., Piper P. J., Williams T. J. The effect of leukotrienes C4 and D4 on the microvasculature of guinea-pig skin. Prostaglandins. 1981 Feb;21(2):315–321. doi: 10.1016/0090-6980(81)90149-0. [DOI] [PubMed] [Google Scholar]
  11. Peck M. J., Williams T. J., Lewis G. P. Prostacyclin (PGI2) potentiates bradykinin-induced plasma exudation in rabbit skin [proceedings]. Br J Pharmacol. 1978 Mar;62(3):464P–465P. [PMC free article] [PubMed] [Google Scholar]
  12. Piper P. J., Said S. I., Vane J. R. Effects on smooth muscle preparations of unidentified vasoactiv peptides from intestine and lung. Nature. 1970 Mar 21;225(5238):1144–1146. doi: 10.1038/2251144a0. [DOI] [PubMed] [Google Scholar]
  13. Polak J. M., Bloom S. R. The distribution and significance of the VIPergic system in man and other mammals. Endocrinol Jpn. 1980 Dec;27 (Suppl 1):11–21. doi: 10.1507/endocrj1954.27.supplement_11. [DOI] [PubMed] [Google Scholar]
  14. Said S. I., Mutt V. Polypeptide with broad biological activity: isolation from small intestine. Science. 1970 Sep 18;169(3951):1217–1218. doi: 10.1126/science.169.3951.1217. [DOI] [PubMed] [Google Scholar]
  15. Wedmore C. V., Williams T. J. Control of vascular permeability by polymorphonuclear leukocytes in inflammation. Nature. 1981 Feb 19;289(5799):646–650. doi: 10.1038/289646a0. [DOI] [PubMed] [Google Scholar]
  16. Williams T. J., Jose P. J. Mediation of increased vascular permeability after complement activation. Histamine-independent action of rabbit C5a. J Exp Med. 1981 Jan 1;153(1):136–153. doi: 10.1084/jem.153.1.136. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Williams T. J., Morley J. Prostaglandins as potentiators of increased vascular permeability in inflammation. Nature. 1973 Nov 23;246(5430):215–217. doi: 10.1038/246215a0. [DOI] [PubMed] [Google Scholar]
  18. Williams T. J., Peck M. J. Role of prostaglandin-mediated vasodilatation in inflammation. Nature. 1977 Dec 8;270(5637):530–532. doi: 10.1038/270530a0. [DOI] [PubMed] [Google Scholar]
  19. Williams T. J., Piper P. J. The action of chemically pure SRS-A on the microcirculation in vivo. Prostaglandins. 1980 May;19(5):779–789. doi: 10.1016/0090-6980(80)90174-4. [DOI] [PubMed] [Google Scholar]
  20. Williams T. J. Prostaglandin E2, prostaglandin I2 and the vascular changes of inflammation. Br J Pharmacol. 1979 Mar;65(3):517–524. doi: 10.1111/j.1476-5381.1979.tb07860.x. [DOI] [PMC free article] [PubMed] [Google Scholar]

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