Abstract
After intramuscular injection of 3.5 mg kg-1 to rabbits, diminazene aceturate shows biphasic pharmacokinetics with maximum blood and interstitial fluid concentrations occurring after 15 min and 3 h respectively. Seven days after treatment, 40-50% of the dose had been excreted in the urine and 8-20% in faeces. Highest diminazene residues were determined in liver: 7 days after dosage, residues of 40.53 +/- 4.00 micrograms g-1 were present, corresponding to 35-50% of the dose. The recommended dose of 3.5 mg kg-1 was not curative for Trypanosoma congolense infections of rabbit but did cause the parasitaemia to become subpatent. A limited prophylactic effect was observed.
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Selected References
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- BAUER F. Trypanosomen- und Babesienerkrankungen in Afrika und ihre Behandlung mit dem neuen Präparat Berenil. Z Tropenmed Parasitol. 1955 Jun;6(2):129–140. [PubMed] [Google Scholar]
- BAUER F. Uber den Wirkungsmechanismus des Berenil (4,4'-Diamidino-diazoaminobenzol) bei Trypanosoma congolgnse. Zentralbl Bakteriol Orig. 1958 Oct;172(7-8):605–620. [PubMed] [Google Scholar]
- Calnan J. S., Ford P. M., Holt P. J., Pflug J. J. Implanted tissue cages--a study in rabbits. Br J Plast Surg. 1972 Apr;25(2):164–174. doi: 10.1016/s0007-1226(72)80040-7. [DOI] [PubMed] [Google Scholar]
- Gilbert R. J., Newton B. A. Ethidium bromide: pharmacokinetics and efficacy against trypanosme infections in rabbits and calves. Parasitology. 1982 Aug;85(Pt 1):127–148. doi: 10.1017/s0031182000054214. [DOI] [PubMed] [Google Scholar]
- Gilbert R. J., Newton B. A. Pharmacokinetics and efficacy of the trypanocide diminazene aceturate (Berenil) in rabbits. Vet Rec. 1982 Oct 23;111(17):397–397. doi: 10.1136/vr.111.17.397. [DOI] [PubMed] [Google Scholar]
- Goodwin L. G., Tierney E. D. Trypanocidal activity of blood and tissue fluid from normal and infected rabbits treated with curative drugs. Parasitology. 1977 Feb;74(1):33–45. doi: 10.1017/s003118200004751x. [DOI] [PubMed] [Google Scholar]
- LUMSDEN W. H., HERBERT W. J., HARDY G. J. IN VIVO PROPHYLACTIC ACTIVITY OF BERENIL AGAINST TRYPANOSOMES IN MICE. Vet Rec. 1965 Jan 30;77:147–148. [PubMed] [Google Scholar]
- Raether W., Hajdú P., Seidenath H., Damm D. Pharmakokinetische und chemoprophylaktische Untersuchungen mit Berenil an Wistar-Ratten (Trypanosoma rhodesiense. Z Tropenmed Parasitol. 1972 Dec;23(4):418–427. [PubMed] [Google Scholar]
- Riegelman S., Loo J. C., Rowland M. Shortcomings in pharmacokinetic analysis by conceiving the body to exhibit properties of a single compartment. J Pharm Sci. 1968 Jan;57(1):117–123. doi: 10.1002/jps.2600570123. [DOI] [PubMed] [Google Scholar]
- WILLIAMSON J. Suramin complexes. I. Prophylactic activity against Trypanosoma congolense in small animals. Ann Trop Med Parasitol. 1957 Dec;51(4):440–456. [PubMed] [Google Scholar]