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. 1993 Apr;175(8):2455–2457. doi: 10.1128/jb.175.8.2455-2457.1993

The Ada protein is a class I transcription factor of Escherichia coli.

K Sakumi 1, K Igarashi 1, M Sekiguchi 1, A Ishihama 1
PMCID: PMC204537  PMID: 8468304

Abstract

The methylated Ada protein of Escherichia coli, a regulatory protein for the adaptive response, binds to a target DNA from positions -62 to -31 upstream of the ada gene and facilitates the binding of RNA polymerase to the promoter. Mutant RNA polymerases consisting of C-terminal-deleted alpha subunits are virtually inactive in response to activation by the Ada protein. Thus, we conclude that the Ada protein is a class I transcription factor which requires the C-terminal region of the RNA polymerase alpha subunit for transcription activation.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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