Skip to main content
PMC home page
The American Journal of Pathology logoLink to The American Journal of Pathology
. 1970 Nov;61(2):117–140.

Ultrastructural pathology of glomerular lesions in gnotobiotic mice with congenital lymphocytic choriomeningitis (LCM) virus infection.

M Kajima, M Pollard
PMCID: PMC2047382  PMID: 4991777

Full text

PDF
120

Images in this article

135Fig 6
on p.135
135Fig 7
on p.135
134Fig 4
on p.134
134Fig 5
on p.134
137Fig 10
on p.137
133Fig 3
on p.133
136Fig 8
on p.136
136Fig 9
on p.136
138Fig 11
on p.138
140Fig 14
on p.140
140Fig 15
on p.140
140Fig 16
on p.140
140Fig 17
on p.140
132Fig 2
on p.132
139Fig 12
on p.139
139Fig 13
on p.139
131Fig 1
on p.131

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Brown P. Evolution of lymphocytic choriomeningitis virus infection from neonatal inoculation through development of adult "late onset disease" and glomerulonephritis. An immunofluorescence study in mice. Arch Gesamte Virusforsch. 1968;24(3):220–230. doi: 10.1007/BF01241294. [DOI] [PubMed] [Google Scholar]
  2. Channing A. A., Kasuga T., Horowitz R. E., Dubois E. L., Demopoulos H. B. An ultrastructural study of spontaneous lupus nephritis in the NZB-BL-NZW mouse. Am J Pathol. 1965 Oct;47(4):677–694. [PMC free article] [PubMed] [Google Scholar]
  3. Comerford F. R., Cohen A. S., Desai R. G. The evolution of the glomerular lesion in NZB mice. A light and electron microscopic study. Lab Invest. 1968 Dec;19(6):643–651. [PubMed] [Google Scholar]
  4. Dalton A. J., Rowe W. P., Smith G. H., Wilsnack R. E., Pugh W. E. Morphological and cytochemical studies on lymphocytic choriomeningitis virus. J Virol. 1968 Dec;2(12):1465–1478. doi: 10.1128/jvi.2.12.1465-1478.1968. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Dubois E. L., Horowitz R. E., Demopoulos H. B., Teplitz R. NZB/NZW mice as a model of systemic lupus erythematosus. JAMA. 1966 Jan 24;195(4):285–289. [PubMed] [Google Scholar]
  6. FELDMAN J. D., HAMMER D., DIXON F. J. Experimental glomerulonephritis. III. Pathogenesis of glomerular ultrastructural lesions in nephrotoxic serum nephritis. Lab Invest. 1963 Jul;12:748–763. [PubMed] [Google Scholar]
  7. FREEDMAN P., MARKOWITZ A. S. Gamma globulin and complement in the diseased kidney. J Clin Invest. 1962 Feb;41:328–334. doi: 10.1172/JCI104486. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Faith G. C., Trump B. F. The glomerular capillary wall in human kidney disease: acute glomerulonephritis, systemic lupus erythematosus, and preeclampsia-eclampsia. Comparative electron microscopic observations and a review. Lab Invest. 1966 Nov;15(11):1682–1719. [PubMed] [Google Scholar]
  9. Good R. A., Finstad J., Cain W. A., Fish A., Perey D. Y., Gatti R. A. Models of immunologic diseases and disorders. Fed Proc. 1969 Jan-Feb;28(1):191–205. [PubMed] [Google Scholar]
  10. Györkey F., Min K. W., Sincovics J. G., Györkey P. Systemic lupus erythematosus and myxovirus. N Engl J Med. 1969 Feb 6;280(6):333–333. doi: 10.1056/nejm196902062800620. [DOI] [PubMed] [Google Scholar]
  11. HOTCHIN J., COLLINS D. N. GLOMERULONEPHRITIS AND LATE ONSET DISEASE OF MICE FOLLOWING NEONATAL VIRUS INFECTION. Nature. 1964 Sep 26;203:1357–1359. doi: 10.1038/2031357a0. [DOI] [PubMed] [Google Scholar]
  12. Henson J. B., Gorham J. R., Tanaka Y. Renal glomerular ultrastructure in mink affected by Aleutian disease. Lab Invest. 1967 Aug;17(2):123–139. [PubMed] [Google Scholar]
  13. Hicks J. D., Burnet F. M. Renal lesions in the "auto-immune" mouse strains NZB and F1 NZBxNZW. J Pathol Bacteriol. 1966 Apr;91(2):467–476. doi: 10.1002/path.1700910221. [DOI] [PubMed] [Google Scholar]
  14. Kajima M., Pollard M. Arterial lesions in gnotobiotic mice congenitally infected with LCM virus. Nature. 1969 Oct 11;224(5215):188–190. doi: 10.1038/224188a0. [DOI] [PubMed] [Google Scholar]
  15. Karstad L., Pridham T. J. Aleutian Disease of Mink: I. Evidence of its Viral Etiology. Can J Comp Med Vet Sci. 1962 May;26(5):97–102. [PMC free article] [PubMed] [Google Scholar]
  16. Kindig D., Spargo B., Kirsten W. H. Glomerular response in Aleutian disease of mink. Lab Invest. 1967 Mar;16(3):436–443. [PubMed] [Google Scholar]
  17. LEE L. Antigen-antibody reaction in the pathogenesis of bilateral renal cortical necrosis. J Exp Med. 1963 Mar 1;117:365–376. doi: 10.1084/jem.117.3.365. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. MELLORS R. C. AUTOIMMUNE DISEASE IN NZB/BL MICE. I. PATHOLOGY AND PATHOGENESIS OF A MODEL SYSTEM OF SPONTANEOUS GLOMERULONEPHRITIS. J Exp Med. 1965 Jul 1;122:25–40. doi: 10.1084/jem.122.1.25. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. MOLLENHAUER H. H. PLASTIC EMBEDDING MIXTURES FOR USE IN ELECTRON MICROSCOPY. Stain Technol. 1964 Mar;39:111–114. [PubMed] [Google Scholar]
  20. MOVAT H. Z. The fine structure of the glomerulus in amyloidosis. Arch Pathol. 1960 Mar;69:323–332. [PubMed] [Google Scholar]
  21. McCluskey R. T., Vassalli P., Gallo G., Baldwin D. S. An immunofluorescent study of pathogenic mechanisms in glomerular diseases. N Engl J Med. 1966 Mar 31;274(13):695–701. doi: 10.1056/NEJM196603312741301. [DOI] [PubMed] [Google Scholar]
  22. Mellors R. C., Huang C. Y. Immunopathology of NZB/BL mice. VI. Virus separable from spleen and pathogenic for Swiss mice. J Exp Med. 1967 Jul 1;126(1):53–62. doi: 10.1084/jem.126.1.53. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Norton W. L. Endothelial inclusions in active lesions of systemic lupus erythematosus. J Lab Clin Med. 1969 Sep;74(3):369–379. [PubMed] [Google Scholar]
  24. Oldstone M. B., Dixon F. J. Lymphocytic choriomeningitis: production of antibody by "tolerant" infected mice. Science. 1967 Dec 1;158(3805):1193–1195. doi: 10.1126/science.158.3805.1193. [DOI] [PubMed] [Google Scholar]
  25. PALADE G. E. A study of fixation for electron microscopy. J Exp Med. 1952 Mar;95(3):285–298. doi: 10.1084/jem.95.3.285. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Padgett G. A., Reiquam C. W., Gorham J. R., Henson J. B., O'Mary C. C. Comparative studies of the Chediak-Higashi syndrome. Am J Pathol. 1967 Oct;51(4):553–571. [PMC free article] [PubMed] [Google Scholar]
  27. Pollard M., Sharon N., Teah B. A. Congenital lymphocytic choriomeningitis virus infection in gnotobiotic mice. Proc Soc Exp Biol Med. 1968 Mar;127(3):755–761. doi: 10.3181/00379727-127-32793. [DOI] [PubMed] [Google Scholar]
  28. SABATINI D. D., BENSCH K., BARRNETT R. J. Cytochemistry and electron microscopy. The preservation of cellular ultrastructure and enzymatic activity by aldehyde fixation. J Cell Biol. 1963 Apr;17:19–58. doi: 10.1083/jcb.17.1.19. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. TREXLER P. C. The gnotobiote-review and future. Biomed Purv. 1961;1:47–58. [PubMed] [Google Scholar]
  30. VASSALLI P., SIMON G., ROUILLER C. ELECTRON MICROSCOPIC STUDY OF GLOMERULAR LESIONS RESULTING FROM INTRAVASCULAR FIBRIN FORMATION. Am J Pathol. 1963 Oct;43:579–617. [PMC free article] [PubMed] [Google Scholar]
  31. VENABLE J. H., COGGESHALL R. A SIMPLIFIED LEAD CITRATE STAIN FOR USE IN ELECTRON MICROSCOPY. J Cell Biol. 1965 May;25:407–408. doi: 10.1083/jcb.25.2.407. [DOI] [PMC free article] [PubMed] [Google Scholar]
  32. WATSON M. L. Staining of tissue sections for electron microscopy with heavy metals. J Biophys Biochem Cytol. 1958 Jul 25;4(4):475–478. doi: 10.1083/jcb.4.4.475. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from The American Journal of Pathology are provided here courtesy of American Society for Investigative Pathology

RESOURCES