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. 1971 Oct;65(1):189–202.

Corticosteroids and the Generalized Shwartzman Reaction

Mechanisms of Sensitization in the Rabbit

Jean-Gilles Latour, Joseph B Prejean, William Margaretten
PMCID: PMC2047505  PMID: 4938095

Abstract

An analysis of the effects of adrenal cortical steroids on the response of the vascular system to bacterial endotoxin has shown that glucocorticoids (cortisone, triamcinolone) are capable of preparing the system for the generalized Shwartzman reaction. On the other hand, the mineralocorticoid desoxycorticosterone acetate does not have this capability. The mechanism of preparation by glucocorticoids has been studied. Administering insulin, with maintenance of normal blood sugar, had no effect on the extent of glomerular capillary thrombosis. Blockade, however, of α-adrenergic receptor sites by Dibenzyline caused a significant reduction of the thrombosis. In addition, cortisone-treated animals did not require exogenous stimulation of α-adrenergic receptor sites by norepinephrine to localize thrombi in the glomerular capillaries when Hageman factor was activated (by ellagic acid) and fibrinolysis inhibited (by ε-aminocaproic acid). It is concluded that glucocorticoids prepare for the generalized Shwartzman reaction by increasing the sensitivity of the microcirculation to stimulation of α-adrenergic receptor sites.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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